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Investigation of the influence of the Mm musculus MyoD1 allele on the efficiency of skeletal muscle regeneration

Published online by Cambridge University Press:  17 April 2001

S. A. MARLOW ,
P. H. KAY ,
J. K. McGEACHIE  and
J. M. PAPADIMITRIOU
S. A. MARLOW
Affiliation:
Department of Pathology, University of Western Australia
P. H. KAY
Affiliation:
Department of Pathology, University of Western Australia
J. K. McGEACHIE
Affiliation:
Department of Anatomy and Human Biology, University of Western Australia
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Abstract

MyoD1 alleles distinguish between the Mm musculus and Mm domesticus subspecies of Mus musculus. SJL/J mice, which belong to the Mm musculus subspecies, are able to regenerate skeletal muscle more efficiently than BALB/c mice which possess the Mm domesticus MyoD1 allele. Hence the possibility that regeneration responses are due to species-specific genetic differences including MyoD1 was investigated in this study. Quantitative morphometric analysis following muscle crush injury of 2 Mm musculus strains, MBK and MGL, has indicated that regeneration phenotype is not species-specific and may not be directly related to MyoD1 alleles. These results contrast with prior investigations conducted in SJL/J and BALB/c mice, and indicate that other genes may have a direct influence on skeletal muscle regeneration.

Keywords

Skeletal muscle injury
Type
Research Article
Information
The Journal of Anatomy , Volume 190 , Issue 2 , February 1997 , pp. 223 - 227
Copyright
© Anatomical Society of Great Britain and Ireland 1997

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