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Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible

  • SHUNICHI SHIBATA (a1), KENJI FUKADA (a2), SHOICHI SUZUKI (a2) and YASUO YAMASHITA (a1)

Abstract

We investigated the immunohistochemical localisation of types II and X collagen as well as the cytochemical localisation of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible on d 14–16 of pregnancy. On d 14 of pregnancy, although no immunostaining for types II and X collagen was observed, alkaline phosphatase activity was detected in all cells in the anlage of the future condylar process. On d 15 of pregnancy, immunostaining for both collagen types was simultaneously detected in the primarily formed condylar cartilage. Alkaline phosphatase activity was also detected in chondrocytes at this stage. By d 16 of pregnancy, the hypertrophic cell zone rapidly increased in size. These findings strongly support a periosteal origin for the condylar cartilage of the fetal mouse mandible, and show that progenitor cells for condylar cartilage rapidly or directly differentiate into hypertrophic chondrocytes.

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Corresponding author

Correspondence to Dr Shunichi Shibata, 1st Department of Oral Anatomy, School of Dentistry, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113, Japan. Tel: 03-5803-5436; fax: 03-5803-0185; e-mail: S.Shibata.oan1@dent.tmd.ac.jp

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Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible

  • SHUNICHI SHIBATA (a1), KENJI FUKADA (a2), SHOICHI SUZUKI (a2) and YASUO YAMASHITA (a1)

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