Skip to main content Accessibility help
×
Home

Effect of angioplasty and grafting on porcine vascular nerves: a potential neurotropic role for endothelin-1

  • M. R. DASHWOOD (a1), G. D. ANGELINI (a2), D. MEHTA (a2), J. Y. JEREMY (a2), K. MUENTER (a3) and M. KIRCHENGAST (a3)...

Abstract

The most commonly performed procedure for treating coronary artery stenosis is percutaneous transluminal coronary angioplasty (PTCA) and, where the vessel lumen is severely narrowed, coronary artery bypass grafting (CABG). In PTCA, regions of atherosclerotic plaques are disrupted, and the vessel lumen increased by inflating a balloon catheter. In CABG an autologous saphenous vein into coronary artery interposition graft is performed in order to bypass occluded regions of epicardial coronary arteries. Both interventions cause varying degrees of vascular damage and the long-term efficacy of these procedures is limited by a high incidence of neointimal formation and subsequent vascular restenosis (Bach et al. 1994; Bryan & Angelini, 1994).

The endothelium-derived constrictor peptide, endothelin-1 (ET-1) (Yanagisawa et al. 1988), also possesses mitogenic activity on vascular smooth muscle cells (Hirata et al. 1989) and has been suggested as playing a role in atherosclerosis (Dashwood et al. 1993; Zeiher et al. 1994) and intimal hyperplasia (Dashwood et al. 1993; Douglas et al. 1994).

Copyright

Corresponding author

Corresponding author.
Type Description Title
PDF

 PDF (471 KB)
471 KB

Effect of angioplasty and grafting on porcine vascular nerves: a potential neurotropic role for endothelin-1

  • M. R. DASHWOOD (a1), G. D. ANGELINI (a2), D. MEHTA (a2), J. Y. JEREMY (a2), K. MUENTER (a3) and M. KIRCHENGAST (a3)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed