Skip to main content Accessibility help

Computer simulation of bovine copper metabolism

  • C. Blincoe (a1)


Copper deficiency in cattle is a world-wide problem. A deterministic digital computer simulation of copper metabolism was applied to cattle and especially to their response to dietary copper. This simulation was verified by comparison with published data on copper metabolism of cattle. Copper loss under conditions of dietary deficiency was governed largely by the rate of hepatic loss of copper. Copper stores were replenished gradually when the animal was returned to a normal diet. The increased copper consumption associated with increased total digestible nutrients (TDN) during lactation compensated for loss of copper in milk. Cattle have a very efficient mechanism for extrahepatic copper homeostasis by storage of excess copper in the liver, which can then be withdrawn in future deficiencies.



Hide All
Bingley, J. B. & Dufty, J. H. (1973). The concentration of copper in whole blood, plasma and erythrocytes of Hereford cattle during pregnancy. Research in Veterinary Science 15, 379380.
Binnerts, W. T. (1965). Use of Cu64 in studies on the copper metabolism in milk cows. In Radioisotopes in Animal Nutrition and Physiology, pp. 357370. Vienna: International Atomic Energy Agency.
Blincoe, C. (1992). Simulation of copper metabolism by mammals. Computers in Biology and Medicine 22, 113122.
Brody, S. (1945). Bioenergetics and Growth. New York: Reinhold Publishing Co.
Chapman, H. L. Jr, & Bell, M. C. (1963). Relative absorption and excretion by beef cattle of copper from various sources. Journal of Animal Science 22, 8285.
Claypool, D. W., Adams, F. W., Pendell, H. W., Hartmann, N. A. Jr. & Bone, J. F. (1975). Relationship between the level of copper in the blood plasma and liver of cattle. Journal of Animal Science 41, 911914.
Comar, C. L., Davis, G. K. & Singer, L. (1948). The fate of radioactive copper administration to the bovine. Journal of Biological Chemistry 174, 905914.
Evans, G. W. & Wiederanders, R. E. (1967). Blood copper variation among species. American Journal of Physiology 213, 11831185.
Fisher, G. L. & Prentice, B. A. (1976). Copper-64 and molybdenum-99 in young cattle with molybdenuminduced copper deficiency. In Molybdenum in the Environment (Eds Chappell, W. R. & Petersen, K. K.), Vol 1, pp. 5174. New York: Marcel Dekker.
Haag, J. R. & Adams, F. W. (1958). Tissue copper relationships and copper status of cattle. Federation Proceedings 17, 477 (Abstract 1872).
Hartmans, J. (1974). Tracing and treating mineral disorders in cattle under field conditions. In Trace Element Metabolism in Animals–2 (Eds Hoekstra, W. G., Suttie, J. W., Ganther, H. E. & Mertz, W.), pp. 261273. Baltimore, MD: University Park Press.
Stoszek, M. J., Mika, P. G., Oldfield, J. E. & Weswig, P. H. (1986). Influence of copper supplementation on blood and liver copper in cattle fed tall fescue or quackgrass. Journal of Animal Science 62, 263271.
Underwood, E. J. (1977). Trace Elements in Human and Animal Nutrition. New York: Academic Press.
Youden, W. J. & Steiner, F. H. (1975). Statistical Manual of the American Association of Official Analytical Chemists. Washington, DC: Association of Official Analytical Chemists.


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed