Skip to main content Accessibility help

Hydrocephalus and bipolar affective disorder

  • Syed Naveed Asif Rizvi (a1), Marie Whitty (a2) and Robert Daly (a3)


Bipolar disorder can emerge in the context of organic brain pathology. In the case presented, long-standing hydrocephalus was diagnosed in a man with relatively late-onset bipolar illness who presented initially with somewhat atypical, treatment-resistant depressive symptoms. Hypomania, followed by a rapid-cycling bipolar course, subsequently developed. This report reviews the association between bipolar disorder and hydrocephalus, and examines possible neurobiological mechanisms implicated in both conditions.


Corresponding author

*Correspondence E-mail:


Hide All
1.Hord, ED. MD, Instructor, Departments of Anesthesia and Neurology, Massachusetts General hospital Pain Centre, Hydrocephalus, Harvard Medical School, Apr 2006.
2.Haslett, C, Edwin, R, Chilvers, B, JHunter, JAA, Boon, NA. Davidson's Principles and Practice of Medicine. 18th ed. Churchill Livingstone, 1999: 1022.
3.Adams, RD, Fisher, CM, Hakim, Set al.Symptomatic occult hydrocephalus with ‘normal’ cerebrospinal fluid pressure; A treatable syndrome. NEJM 1965; 273: 117126.
4.J Pulol, S, Leal, X, Conde Fand, C. Psychiatric aspects of Normal-Pressure Hydrocephalus, A report of five cases. Br J Psych 1989; 154 (suppl. 4): 7780.
5.Reisch, T, Brekenfeld, C, Barth, A. A case of hydrocephalus occlusus presenting as bipola disorder. Acta Psychiatr Scand 2005: 112: 159163.
6.Kwentus, JA, Hart, RP. Normal pressure hydrocephalus presenting as mania. J Nerv Ment Dis 1987; 175: 500502.
7.Monji, A, Yoshida, I. Brain Injury – Induces Rapid Cycling Affective Disorder Successfully Treated With Valproate. Psychosomatics 1999; 40: 5.
8.Pinner, G, Johnson, H, Bouman, WP, Isaacs, J. Psychiatric manifestation of normal pressure hydrocephalus: a short review and unusual case. Int Psychogeriatrics 1997; 9: 465470.
9.Diley, M. Fleminger, S. Advances in neuropsychiatry: clinical implications. Advances in Psychiatric Treatment 2006; 12: 2324.
10.Schneider, U, Malmadier, A, Dengler, R, Sollmann, WP, Emrich, HM. Mood Cycles Associated With Normal Pressure Hydrocephalus. Am J Psych 1996; 153: 10.
11.Pearlson, GD, Garbacz, DJ, Tompkins, RHet al.Clinical Correlates of Lateral Ventriclar Enlargement in Bipolar Affective Disorder. Am J Psych 1984; 141: 253256.
12.Jinkins, JR. Clinical manifestations of hydrcephalus caused by impingement of the corpus callosum on the falx: an MR study in 40 patients. Am J Neuroradiol 1991; 12(2): 331340.
13.Kempton, MJ, Geddes, JR, Ettinger, U, Williams, SCR, Grasby, PM. Meta-analysis, Database, and Meta-regression of 98 Structural Imaging Studies in Bipolar Disorder. Arch Gen Psych 2008; 65(9).
14.Baxter, LR, Phelps, ME, Mazziotta, JCet al.Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F18. Arch Gen Psychi 1985; 42: 441447.
15.Baumann, B, Danos, P, Krell, Det al.Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a post mortem study. J Neuropsych Clin Neurosci 1999; 11: 7178.



Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed