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Delayed Onset of Neuropsychiatric Effects Associated with Montelukast

Published online by Cambridge University Press:  13 June 2014

Fintan Byrne ,
Bolarinwa Oluwole ,
Vanessa Whyte ,
Sabina Fahy  and
Delia McGuinness
Fintan Byrne*
Affiliation:
University Hospital Galwayand National University of Ireland Galway, Ireland
Bolarinwa Oluwole
Affiliation:
London Health Sciences Centre, London, Ontario, Canada
Vanessa Whyte
Affiliation:
Castle St Surgery, Roscommon Town, Co. Roscommon, Ireland
Sabina Fahy
Affiliation:
St. Brigids Hospital, Ballinasloe, Co. Galway, Ireland
Delia McGuinness
Affiliation:
CAMHS, Ballard House, Galway, Ireland
*
*Correspondence Email: fintanbyrne@gmail.com
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Abstract

Montelukast (a leukotriene receptor antagonist) is a commonly prescribed medication used in the management of asthma in both children and adults. It has been associated with a possible increased risk of various neuropsychiatric events in post-marketing analyses of clinical trial data and surveillance studies. When establishing a link between a medication and side effects, it is usual to establish and enquire whether there is a chronological relationship between the commencement of the medication and the onset of the symptoms.

We report a case where a number of unusual neuropsychiatric events were reported several years after commencement of montelukast in a young boy who may have a genetic predisposition and a likely psychological trigger. There was complete resolution of these symptoms upon the withdrawal of montelukast.

Keywords

Asthmamontelukastleukotriene receptor antagonistdelayed onset adverse effectsneuropsychiatric adverse effects.
Type
Case Report
Information
Irish Journal of Psychological Medicine , Volume 29 , Issue 2 , 2012 , pp. 125 - 127
Copyright
Copyright © Cambridge University Press 2012

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