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Co-prescribing of linezolid and serotonergic agents in a general hospital setting

  • C. Clarke (a1), M. Finnegan (a2), A. M. O’Dwyer (a3), C. Mc Donald (a4), B. O’Connell (a5) and J. Cooney (a3)...

Abstract

Background

Co-prescription of linezolid and serotonergic agents (SSRIs, SNRIs, NaSSA, TCAs) can lead to serotonin syndrome, this study seeks to identify prescribing practise of these agents.

Methods

Study of all general hospital inpatients prescribed intravenous linezolid in a 3-month period, using drug charts and clinical notes.

Results

Co-prescription occurred in 20% with SSRIs most frequently concurrently used. There were no cases of serotonin syndrome. There was no evidence in clinical notes of vigilance for potential interaction.

Conclusion

Co-prescription is common; awareness of potentially serious interaction is not evident in current practice.

Copyright

Corresponding author

*Address for correspondence: Dr C. Clarke, Central Mental Hospital, Dundrum, Dublin 14, Ireland. (Email: caoimhenichleirigh@hotmail.com)

References

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Cantarini, MV, Painter, CJ, Hughes, AM (2004). Effect of oral linezolid on the pressor response to intravenous tyramine. British Journal of Clinical Pharmacology 58, 470475.
Falagas, ME, Vardakas, KZ (2008). Benefit-risk assessment of linezolid for serious gram-positive bacterial infections. Drug Safety: An International Journal of Medical Toxicology and Drug Experience 31, 753768.
Farrell, J (2007). Zyvox: summary of product characteristics (http://www.imb.ie/images/uploaded/documents/Zyvox). Accessed 21 November 2011.
Lawrence, KR, Adra, M, Gillman, PK (2006). Serotonin toxicity associated with the use of linezolid: a review of postmarketing data. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 42, 15781583.
Pfizer Healthcare Ireland (2012). Zyvox: summary of product characteristics (http://www.medicines.ie). Accessed 21 May 2012.
Quinn, DK, Stern, TA (2009). Linezolid and serotonin syndrome. Primary Care Companion to the Journal of Clinical Psychiatry 11, 353356.
Taylor, JJ, Wilson, JW, Estes, LL (2006). Linezolid and serotonergic drug interactions: a retrospective survey. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 43, 180187.
Vardakas, KZ, Ntziora, F, Falagas, ME (2007). Linezolid: effectiveness and safety for approved and off-label indications. Expert Opinion on Pharmacotherapy 8, 23812400.

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Co-prescribing of linezolid and serotonergic agents in a general hospital setting

  • C. Clarke (a1), M. Finnegan (a2), A. M. O’Dwyer (a3), C. Mc Donald (a4), B. O’Connell (a5) and J. Cooney (a3)...

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