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Irish Journal of Psychological Medicine Irish Journal of Psychological Medicine

Article contents

Clozapine induced myocarditis: a case report and literature review

Published online by Cambridge University Press:  13 June 2014

Sunday O Okereke ,
Wan MY Mohd Abdoh  and
Bernadette M Murphy
Sunday O Okereke
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Wan MY Mohd Abdoh
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Bernadette M Murphy
Affiliation:
Department of Psychiatry, Adelaide and Meath Hospital including the National Children's Hospital, Tallaght, Dublin 24, Ireland
Corresponding
E-mail address:
bcantillonmurphy@hotmail.com
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Abstract

Clozapine, the drug of choice for treatment resistant schizophrenia, has a range of serious cardiac side-effects. This paper describes a fatal case of myocarditis in a 48 year old man four weeks after starting clozapine. In particular, this case illustrates how incipient the disorder can be and the need for a high level of suspicion. Difficulties in diagnosing clozapine induced myocarditis and ways to minimise its risk are also discussed.

Keywords

Clozapine Myocarditis Schizophrenia
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 26 , Issue 3 , September 2009 , pp. 147 - 148
Copyright
Copyright © Cambridge University Press 2009

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References

1.Clozapine, SPC (Date of revision November 2005). Electronic Medicines Compendium (eMC). http://emc.medicines.org.uk (accessed 12 December 2008).Google Scholar
2.Merrill, DB, Dec, GW, Goff, DC. Adverse Cardiac Effects Associated With Clozapine. J Clin Psychopharmacol 2005; 25(1): 32–41.CrossRefGoogle ScholarPubMed
3.Meltzer, HY, Cola, P, Way, L, Thompson, PA, Bastani, B, Daves, MA, et al.Cost effectiveness of clozapine in neuroleptic-resistant schizophrenia. Am J Psych 1993; 150:1630–8.Google ScholarPubMed
4.Hass, SJ, Hill, R, Krum, H, Liew, D, Tonkin, A, Demos, L, et al.Clozapine-associated myocarditis: A review of 116 Cases of Suspected Myocarditis Associated with the use of Clozapine in Australia during 1993-2003. Drug Saf 2007; 30 (1): 47–57.CrossRefGoogle Scholar
5.Hagg, S, Spigseto, O, Bate, A, Soderstrom, TG. Myocarditis related to clozapine treatment. J Clin Psychopharmacol 2001; 21:382–8.CrossRefGoogle ScholarPubMed
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7.Pieroni, M, Cavallaro, R, Chimenti, C, Smeraldi, E, Frustaci, A. Clozapine-induced hypersensitivity myocarditis. Chest 2004; 126: 1703–5.CrossRefGoogle ScholarPubMed

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