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Working memory span in mild cognitive impairment. Influence of processing speed and cognitive reserve

  • David Facal (a1), Onésimo Juncos-Rabadán (a1), Arturo X. Pereiro (a1) and Cristina Lojo-Seoane (a1)

Abstract

Background:

Mild cognitive impairment (MCI) often includes episodic memory impairment, but can also involve other types of cognitive decline. Although previous studies have shown poorer performance of MCI patients in working memory (WM) span tasks, different MCI subgroups were not studied.

Methods:

In the present exploratory study, 145 participants underwent extensive cognitive evaluation, which included three different WM span tasks, and were classified into the following groups: multiple-domain amnestic MCI (mda-MCI), single-domain amnestic MCI (sda-MCI), and controls. General linear model was conducted by considering the WM span tasks as the within-subject factor; the group (mda-MCI, sda-MCI, and controls) as the inter-subject factor; and processing speed, vocabulary and age as covariates. Multiple linear regression models were also used to test the influence of processing speed, vocabulary, and other cognitive reserve (CR) proxies.

Results:

Results indicate different levels of impairment of WM, with more severe impairment in mda-MCI patients. The differences were still present when processing resources and CR were controlled.

Conclusions:

Between-group differences can be understood as a manifestation of the greater severity and widespread memory impairment in mda-MCI patients and may contribute to a better understanding of continuum from normal controls to mda-MCI patients. Processing speed and CR have a limited influence on WM scores, reducing but not removing differences between groups.

Copyright

Corresponding author

Correspondence should be addressed to: Dr. David Facal, Department of Developmental and Educational Psychology, University of Santiago de Compostela, Campus Sur, 15782 Santiago de Compostela, Spain. Phone: +34-881813695; Fax: +34-981528071. Email: david.facal@usc.es.

References

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Albert, M. S. et al. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7, 270279. doi:10.1016/j.jalz.2011.03.008.
Aretouli, E. and Brandt, J. (2009). Everyday functioning in mild cognitive impairment and its relationship with executive cognition. International Journal of Geriatric Psychiatry, 25, 224233. doi:10.1002/gps.2325.
Belanger, S. and Belleville, S. (2009). Semantic inhibition impairment in mild cognitive impairment: a distinctive feature of upcoming cognitive decline? Neuropsychology, 23, 592606. doi:10.1037/a0016152.
Belleville, S., Chertkow, H. and Gauthier, S. (2007). Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment. Neuropsychology, 21, 458469.
Belleville, S., Sylvain-Roy, S., de Boysson, C. and Ménard, M. C. (2008). Characterizing the memory changes in persons with mild cognitive impairment. In Sossin, W. S., Lacaille, J.-C., Castellucci, V. F. and Belleville, S. (eds.), Progress in Brain Research Essence of Memory, 365375. Amsterdam, Netherlands: Elsevier Science. doi:10.1016/S0079-6123(07)00023-4.
Benedet, M. J. and Alejandre, M. A. (1998). TAVEC: Test de Aprendizaje Verbal España-Complutense. Madrid, Spain: Tea Ediciones.
Benedet, M. J. and Seisdedos, N. (1996). Evaluación clínica de las quejas de la memoria en la vida cotidiana. Madrid, Spain: Editorial Médica Panamericana, SA.
Blair, M-, Vadaga, K. K., Shuchat, J. and Li, K. Z. H. (2011). The role of age and inhibitory efficiency in working memory processing and storage components. Quarterly Journal of Experimental Psychology, 64, 11571172.
Brandt, J., Aretouli, E., Neijstrom, E., Samek, J., Manning, K. and Albert, M. S. (2009). Selectivity of executive function deficits in mild cognitive impairment. Neuropsychology, 23, 607618. doi:10.1037/a0015851.
Buckner, R. L. (2004). Memory and executive function review in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron, 44, 195208.
Carretti, B., Borella, E., Fostinelli, S. and Zavagnin, M. (2013). Benefits of training working memory in amnestic mild cognitive impairment: specific and transfer effects. International Psychogeriatrics, 25, 617626. doi:10.1017/S1041610212002177.
Case, R., Kurland, M. D. and Goldberg, J. (1982). Operational efficiency and the growth of short-term memory span. Journal of Experimental Child Psychology, 33, 386404.
Conway, A. R. A., Kane, M. J. and Engle, R. W. (2003). Working memory capacity and its relation to general intelligence. Trends in Cognitive Science, 7, 547552.
Daneman, M. and Carpenter, P. (1980). Individual differences in working memory and reading. Journal of Verbal Learning & Verbal Behavior, 19, 450466.
Economou, A., Papageorgiou, S. and Karageorgiou, C. (2006). Working-delayed memory difference detects mild cognitive impairment without being affected by age and education. Journal of Clinical and Experimental Neuropsychology, 28, 528535.
Economou, A., Papageorgiou, S., Karageorgiou, C. and Vassilopoulos, D. (2007). Nonepisodic memory deficits in amnestic MCI. Cognitive and Behavioral Neurology, 20, 99106.
Friedman, N. P. and Miyake, A. (2004). The reading span test and its predictive power for reading comprehension ability. Journal of Memory and Language, 51, 136158.
Gagnon, L. G. and Belleville, S. (2011). Working memory in mild cognitive impairment and Alzheimer's disease: contribution of forgetting and predictive value of complex span tasks. Neuropsychology, 25, 226236. doi:10.1037/a0020919.
Garibotto, V. et al. (2008). Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology, 71, 13421349. doi:10.1212/01.wnl.0000327670.62378.c0.
Lawton, M. P. and Brody, E. M. (1969). Assesment of older people: selfmaintaining and instrumental activities of daily living. The Gerontologist, 3, 179186.
Lobo, A. et al. (1999). Revalidación y normalización del Mini-Examen Cognoscitivo (primera versión en castellano del Mini-Mental Status Examination) en la población general geríátrica. Medicina Clínica, 112, 767774.
Lojo-Seoane, C., Facal, D. and Juncos-Rabadán, O. (2012) ¿Previene la actividad intelectual el deterioro cognitivo? Relaciones entre reserva cognitiva y deterioro cognitivo ligero. Revista Española de Geriatría y Gerontología, 47, 270278. doi:10.1016/j.regg.2012.02.006.
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194.
Robbins, T. W., James, M., Owen, A. M., Sahakian, B. J., McInnes, L. and Rabbitt, P. (1994). Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia, 5, 266281.
Roth, M., Huppert, F. A., Mountjoy, C. Q. and Tym, E. (1999). CAMDEX-R: The Cambridge Examination for Mental Disorders of the Elderly (Revised). Cambridge, UK: Cambridge University Press.
Salthouse, T. and Babcock, R. (1991). Decomposing adult age differences in working memory. Developmental Psychology, 27, 763776.
Salthouse, T. A. and Davis, H. P. (2006). Organization of cognitive abilities and neuropsychological variables across the lifespan. Developmental Review, 26, 3154.
Schmand, B., Smith, J. H., Geerlings, M. I. and Lindeboom, J. (1997). The effects of intelligence and education on the development of dementia: a test of the brain reserve hypothesis. Psychological Medicine: A Journal of Research in Psychiatry and the Allied Sciences, 27, 13371344. doi:10.1017/S0033291797005461.
Solé-Padullés, C. et al. (2009). Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 30, 11141124. doi:10.1016/j.neurobiolaging.2007.10.008.
Stern, Y. (2009). Cognitive reserve. Neuropsychologia, 47, 20152028. doi:10.1016/j.neuropsychologia.2009.03.004.
Unsworth, N., Redick, T., Heitz, R., Broadway, J. and Engle, R. (2009). Complex working memory span tasks and higher-order cognition: a latent-variable analysis of the relationship between processing and storage. Memory, 17, 635654.
Wechsler, D. (1988). WAIS. Escala de Inteligencia de Wechsler para Adultos. Madrid, Spain: TEA Ediciones.
Wu Nordahl, C., Ranganath, C., Yonelinas, A. P., DeCarli, C., Reed, B. R. and Jagust, W. J. (2005). Different mechanisms of episodic memory failure in mild cognitive impairment. Neuropsychologia, 43, 16881697.

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Working memory span in mild cognitive impairment. Influence of processing speed and cognitive reserve

  • David Facal (a1), Onésimo Juncos-Rabadán (a1), Arturo X. Pereiro (a1) and Cristina Lojo-Seoane (a1)

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