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Validation of the Chinese version of the memory binding test for distinguishing amnestic mild cognitive impairment from cognitively normal elderly individuals

Published online by Cambridge University Press:  29 October 2019

Xiao Wang ,
Tao Li ,
Haifeng Zhang ,
Tingting Sun ,
Lingchuan Xiong ,
Yunqiu Zhang ,
Zhiyu Sun ,
Xin Yu  and
Huali Wang Open the ORCID record for Huali Wang [Opens in a new window]
Xiao Wang
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key Laboratory of Mental Health, National Health Commission, Beijing, China Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, China
Tao Li
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key Laboratory of Mental Health, National Health Commission, Beijing, China
Haifeng Zhang
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key Laboratory of Mental Health, National Health Commission, Beijing, China
Tingting Sun
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key Laboratory of Mental Health, National Health Commission, Beijing, China
Lingchuan Xiong
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China
Yunqiu Zhang
Affiliation:
Capital Normal University, Beijing, China
Zhiyu Sun
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Graduate School of Medicine, Wenzhou Medical University, Wenzhou, China
Xin Yu
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key Laboratory of Mental Health, National Health Commission, Beijing, China
Huali Wang*
Affiliation:
Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing, China Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Beijing, China National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Key Laboratory of Mental Health, National Health Commission, Beijing, China
*
Correspondence should be addressed to: Huali Wang, Peking University Institute of Mental Health, No. 51 Huayuanbei Road, Haidian District, Beijing 100191, China. Phone: +86-10-82801983. Email: huali_wang@bjmu.edu.cn.
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Abstract

Background:

Episodic memory starts to decline very early in the development of Alzheimer’s disease (AD). Subtle impairments in memory binding may be detected in mild cognitive impairment (MCI). This study aims to examine the psychometric properties of the Chinese version of the memory binding test (MBT).

Methods:

One hundred and sixty-four subjects (26 individuals with AD, 67 individuals with amnestic MCI (aMCI), 30 individuals with subjective cognitive impairment (SCI), and 41 cognitively normal elderly individuals (NC)) participated in the study. Twenty-two subjects repeated the assessment of the MBT within 6 weeks (± 2 weeks). Pearson correlation was used to calculate the convergent validity. The test––retest reliability was determined by the calculation of the intraclass correlation coefficient (ICC). Discriminative validity was calculated to evaluate the receiver–operating characteristic curves. The optimal index was chosen by comparing the area under the curve for specificity and sensitivity ≥ 0.80. The optimal cutoff score of the index was chosen to maximize the sum of sensitivity and specificity.

Results:

The absolute value of the convergent validity of the direct indexes of MBT ranged from 0.443 to 0.684. The ICC for each of direct indexes was 0.887–0.958. Total delayed paired recall (TDPR) was the optimal index for discriminating aMCI from NC. The cutoff score for TDPR was ≤25 to distinguish aMCI from NC (sensitivity = 0.896, specificity = 0.707).

Conclusion:

The Chinese version of MBT is a valid and reliable instrument to detect MCI.

Keywords

memory binding testvalidityreliabilityepisodic memorymemory bindingmild cognitive impairment
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 12: Issue Theme: Assessment of Cognitive Impairment in East Asia , December 2019 , pp. 1721 - 1730
Copyright
© International Psychogeriatric Association 2019 

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Footnotes

†

Both the authors contributed equally to this work.

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