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Subcortical Ischemic Vascular Disease and Dementia

Published online by Cambridge University Press:  10 January 2005

Timo Erkinjuntti
Affiliation:
Department of Neurology, University of Helsinki, Helsinki, Finland

Abstract

Subcortical ischemic vascular disease and dementia (SIVD) incorporate small vessel disease as the chief vascular etiology, lacunar infarct and ischemic white-matter lesions (WMLs) as primary type of brain lesions, subcortical location as the primary location of lesions, and subcortical syndrome as the primary clinical manifestation. It incorporates two clinical entities: Binswanger's syndrome and the lacunar state. Patients with SIVD present with extensive white-matter lesions and multiple lacunae on neuroimaging. SIVD is expected to be a more homogenous subtype of vascular cognitive impairment and dementia. Recently modified NINDS-AIREN research criteria for SIVD have been proposed. Further empirical research is needed to refine the syndrome and stages and validate the brain imaging criteria, as well as to detail the natural history and outcomes of SIVD.

Type
BACKGROUND AND CURRENT CONCEPTS OF ETIOPATHOGENESIS
Copyright
© 2003 International Psychogeriatric Association

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