Skip to main content Accessibility help
×
Home

Staging: Relevance for Trial Design in Vascular Burden of the Brain

  • Barry Reisberg (a1), Steven H. Ferris (a1), Thet Oo (a1) and Emile Franssen (a1)

Abstract

Cerebrovascular small vessel disease is now believed to be the major source of vascular burden of the brain. Cerebrovascular small vessel disease and Alzheimer's disease appear to represent pathophysiologic and clinical continua, rather than dichotomous entities. It appears that common etiopathologic mechanisms underlie the clinical presentation of both of these conditions. Therefore, the staging procedures that have been developed for the clinical continuum of age-associated memory impairment, mild cognitive impairment, and the progressive dementia of Alzheimer's disease appear to be applicable for the same continua in cerebrovascular small vessel disease. Although temporal and prognostic aspects have been studied for the Alzheimer's-related portions of this clinical staging continuum, they remain to be elucidated for cerebrovascular small vessel disease.

Copyright

Keywords

Related content

Powered by UNSILO

Staging: Relevance for Trial Design in Vascular Burden of the Brain

  • Barry Reisberg (a1), Steven H. Ferris (a1), Thet Oo (a1) and Emile Franssen (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.