Skip to main content Accessibility help
×
Home

Semantic clustering and sleep in patients with amnestic mild cognitive impairment or with vascular cognitive impairment-no dementia

  • Qingna Sun (a1), Lanlan Luo (a1), Honglei Ren (a1), Changjuan Wei (a1), Mengya Xing (a1), Yan Cheng (a1) and Nan Zhang (a1)...

Abstract

Background:

Cognition and sleep deficits occur in amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment-no dementia (VCIND). However, how memory and sleep deficits differ between aMCI and VCIND remains unclear.

Methods:

Fifty aMCI and 50 VCIND patients and 38 sex- and age-matched healthy controls (HCs) were administered the Hopkins Verbal Learning Test-Revised (HVLT-R), Trail Making Test-A/B (TMT-A/B), Wisconsin Card Sorting Test (WCST), Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Benton Judgment of Line Orientation (JLO) test, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Insomnia Severity Index (ISI) to quantify cognitive deficits and subjective sleep disturbance.

Results:

Compared with VCIND patients, aMCI patients had lower HVLT-R scores for total recall (p < 0.001), delayed recall (p < 0.001) and recognition (p = 0.001), and for total-recall (p = 0.002) and delayed-recall (p < 0.001) semantic clustering ratios (SCRs). However, VCIND patients exhibited more obvious executive dysfunction (TMT-A, p < 0.001; TMT-B, p < 0.001; WCST, p < 0.001), lower information processing speed (PASAT, p = 0.003; SDMT, p < 0.001), and more severe sleep disturbance (PSQI, p < 0.001; ESS, p < 0.001; ISI, p < 0.001). Additionally, sleep quality and efficiency were related to total and delayed recall (all r values from −0.31 to −0.60, p < 0.05) in aMCI and VCIND.

Conclusions:

aMCI and VCIND differ in cognitive function, memory strategy and sleep impairment; these characteristics are helpful to identify and distinguish patients with very early cognitive impairment. Our results also suggest that memory deficits are associated with sleep disturbance in aMCI and VCIND.

Copyright

Corresponding author

Correspondence should be addressed to: Nan Zhang, MD, PhD, Department of Neurology, Tianjin Medical University General Hospital, 154, Anshan Road, Tianjin 300052, China. Phone: +8622 60814622; Fax: +8622 60817471. Email: nkzhangnan@yeah.net.

References

Hide All
Baddeley, A. D. (2001). Is working memory still working?. The American Psychologist, 56, 851864.
Bassetti, C. L. and Hermann, D. M. (2011). Sleep and stroke. Handbook of Clinical Neurology, 99, 10511072.
Bastien, C. H., Vallieres, A. and Morin, C. M. (2001). Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Medicine, 2, 297307.
Benton, A. L. (1994). Neuropsychological assessment. Annual Review of Psychology, 45, 123.
Berg, L. (1988). Clinical dementia rating (CDR). Psychopharmacology Bulletin, 24, 637639.
Chee, M. W. and Chuah, L. Y. (2008). Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition. Current Opinion in Neurology, 21, 417423.
Cheng, C. Y., Tsai, C. F., Wang, S. J., Hsu, C. Y. and Fuh, J. L. (2013). Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia. Journal of Geriatrics Psychiatry and Neurology, 26, 158164.
Cho, Y. W., Lee, J. H., Son, H. K., Lee, S. H., Shin, C. and Johns, M. W. (2011). The reliability and validity of the Korean version of the Epworth sleepiness scale. Sleep & Breathing, 15, 377384.
Diekelmann, S. and Born, J. (2010). The memory function of sleep. Nature Reviews. Neuroscience, 11, 114126.
Frisoni, G. B., Galluzzi, S., Bresciani, L., Zanetti, O. and Geroldi, C. (2002). Mild cognitive impairment with subcortical vascular features: clinical characteristics and outcome. Journal of Neurology, 249, 14231432.
Fuh, J. L., Wang, S. J. and Cummings, J. L. (2005). Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 76, 13371341.
Gaines, J. J., Shapiro, A., Alt, M. and Benedict, R. H. (2006). Semantic clustering indexes for the Hopkins verbal learning test-revised: initial exploration in elder control and dementia groups. Applied Neuropsychology, 13, 213222.
Gronwall, D. M. (1977). Paced auditory serial-addition task: a measure of recovery from concussion. Perceptual and Motor Skills, 44, 367373.
Grothe, M. et al. (2010). Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer's disease. Cerebral Cortex, 20, 16851695.
Hachinski, V. et al. (2006). National institute of neurological disorders and stroke-Canadian stroke network vascular cognitive impairment harmonization standards. Stroke, 37, 22202241.
Hirshkowitz, M. (2004). Normal human sleep: an overview. The Medical Clinics of North America, 88, 551565, vii.
Hita-Yanez, E., Atienza, M. and Cantero, J. L. (2013). Polysomnographic and subjective sleep markers of mild cognitive impairment. Sleep, 36, 13271334.
Ingles, J. L., Wentzel, C., Fisk, J. D. and Rockwood, K. (2002). Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment, without dementia. Stroke, 33, 19992002.
Jiang, B. et al. (2013). Polysomnographic abnormalities in patients with vascular cognitive impairment-no dementia. Sleep Medicine, 14, 10711075.
Joo, B. E. et al. (2011). Prevalence of sleep-disordered breathing in acute ischemic stroke as determined using a portable sleep apnea monitoring device in Korean subjects. Sleep & Breathing, 15, 7782.
Kloepfer, C. et al. (2009). Memory before and after sleep in patients with moderate obstructive sleep apnea. Journal of Clinical Sleep Medicine, 5, 540548.
Lawton, M. P. and Brody, E. M. (1969). Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 9, 179186.
Malek-Ahmadi, M., Raj, A. and Small, B. J. (2011). Semantic clustering as a neuropsychological predictor for amnestic-MCI. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition, 18, 280292.
Marra, C., Ferraccioli, M., Vita, M. G., Quaranta, D. and Gainotti, G. (2011). Patterns of cognitive decline and rates of conversion to dementia in patients with degenerative and vascular forms of MCI. Current Alzheimer Research, 8, 2431.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology, 34, 939944.
McLaughlin, P. M. et al. (2014). The “Alzheimer's type” profile of semantic clustering in amnestic mild cognitive impairment. Journal of the International Neuropsychological Society, 20, 402412.
Meyer, J. S., Xu, G., Thornby, J., Chowdhury, M. H. and Quach, M. (2002). Is mild cognitive impairment prodromal for vascular dementia like Alzheimer's disease?. Stroke, 33, 19811985.
Mok, V. C. et al. (2004). The validity and reliability of chinese frontal assessment battery in evaluating executive dysfunction among Chinese patients with small subcortical infarct. Alzheimer Disease and Associated Disorders, 18, 68v74.
Nordlund, A., Rolstad, S., Klang, O., Lind, K., Hansen, S. and Wallin, A. (2007). Cognitive profiles of mild cognitive impairment with and without vascular disease. Neuropsychology, 21, 706712.
O'Brien, J. T. et al. (2003). Vascular cognitive impairment. The Lancet Neurology, 2, 8998.
Petersen, R. C. et al. (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58, 19851992.
Porkka-Heiskanen, T., Zitting, K. M. and Wigren, H. K. (2013). Sleep, its regulation and possible mechanisms of sleep disturbances. Acta Physiologica, 208, 311328.
Price, S. E. et al. (2010). Learning and memory in amnestic mild cognitive impairment: contribution of working memory. Journal of the International Neuropsychological Society, 16, 342351.
Ribeiro, F., Guerreiro, M. and De Mendonca, A. (2007). Verbal learning and memory deficits in mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 29, 187197.
Rossini, E. D. and Karl, M. A. (1994). The trail making test A and B: a technical note on structural nonequivalence. Perceptual and Motor Skills, 78, 625626.
Schwartz, J. R. and Roth, T. (2008). Neurophysiology of sleep and wakefulness: basic science and clinical implications. Current Neuropharmacology, 6, 367378.
Shi, J., Tian, J., Wei, M., Miao, Y. and Wang, Y. (2012). The utility of the Hopkins verbal learning test (Chinese version) for screening dementia and mild cognitive impairment in a Chinese population. BMC Neurology, 12, 136.
Smith, A. (1982). Symbol Digit Modalities Test. Los Angeles, CA: Western Psychological Services.
Sohn, S. I., Kim do, H., Lee, M. Y. and Cho, Y. W. (2012). The reliability and validity of the Korean version of the pittsburgh sleep quality index. Sleep & Breathing, 16, 803812.
Takeuchi, M. et al. (2014). Does sleep improve memory organization?. Frontiers in Behavioral Neuroscience, 8, 65.
Vasquez, B. P. and Zakzanis, K. K. (2015). The neuropsychological profile of vascular cognitive impairment not demented: a meta-analysis. Journal of Neuropsychology, 9, 109136.
Villeneuve, S., Massoud, F., Bocti, C., Gauthier, S. and Belleville, S. (2011). The nature of episodic memory deficits in MCI with and without vascular burden. Neuropsychologia, 49, 30273035.
Westerberg, C. E. et al. (2010). Sleep influences the severity of memory disruption in amnestic mild cognitive impairment: results from sleep self-assessment and continuous activity monitoring. Alzheimer Disease and Associated Disorders, 24, 325333.
Westerberg, C. E. et al. (2012). Concurrent impairments in sleep and memory in amnestic mild cognitive impairment. Journal of the International Neuropsychological Society, 18, 490500.
Winblad, B. et al. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. Journal of Internal Medicine, 256, 240246.
Yu, J., Li, J. and Huang, X. (2012). The Beijing version of the montreal cognitive assessment as a brief screening tool for mild cognitive impairment: a community-based study. BMC Psychiatry, 12, 156.
Zanetti, M., Ballabio, C., Abbate, C., Cutaia, C., Vergani, C. and Bergamaschini, L. (2006). Mild cognitive impairment subtypes and vascular dementia in community-dwelling elderly people: a 3-year follow-up study. Journal of the American Geriatrics Society, 54, 580586.
Zheng, Y. P. and Lin, K. M. (1991). Comparison of the Chinese depression inventory and the Chinese version of the beck depression inventory. Acta Psychiatrica Scandinavica, 84, 531536.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed