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Progress of leukoaraiosis is inhibited by correction of platelet hyper-aggregability

  • Shigekiyo Fujita (a1), Tetsuro Kawaguchi (a2), Toshiyuki Uehara (a2) and Kazuhito Fukushima (a3)

Abstract

Background: Platelet hyper-aggregability is an important risk factor for leukoaraiosis. In this study we investigated whether aggravation of leukoaraiosis can be controlled by means of long-term correction of platelet hyper-aggregability.

Methods:Twenty-one patients with leukoaraiosis and uncorrected platelet hyper-aggregability were compared with 21 controls matched for age, grade of leukoaraiosis and observation period whose platelet hyper-aggregability was corrected. Platelet aggregability was estimated by an optical analytical method with a nine-stage display using two different concentrations each of adenosine diphosphate (ADP) and collagen (the double ADP method).

Results:The mean observation period between two magnetic resonance imaging (MRI) scans for both groups was 4.1 years. In the non-corrected group, moderate to severe aggravation of leukoaraiosis was observed in a large number of patients. In the corrected group, only a small number of patients showed generally mild aggravation of leukoaraiosis. The number of patients showing aggravation of periventricular hyperintensity (PVH) was 7 in 21 in the non-corrected group versus 1 in 21 (p=0.022) in the corrected group, and for aggravation of deep white-matter hyperintensity, these values were 9 in 21 versus 4 in 21, respectively. Thus, the difference was more significant if the degree of aggravation was taken into account.

Conclusion:The progress of leukoaraiosis is greatly inhibited by long-term correction of platelet hyper-aggregability.

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Corresponding author

Correspondence should be addressed to: Shigekiyo Fujita, Institute for Advanced Neurological Medicine and Computed Imaging, Ishikawa Hospital, 784, Bessho, Bessho-cho, Himeji, 671-0221, Japan. Phone: +81-792-52–5235; Fax: +81-792-53-8116. Email: fujitas@oak.ocn.ne.jp.

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Progress of leukoaraiosis is inhibited by correction of platelet hyper-aggregability

  • Shigekiyo Fujita (a1), Tetsuro Kawaguchi (a2), Toshiyuki Uehara (a2) and Kazuhito Fukushima (a3)

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