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Prescribing patterns of low doses of antipsychotic medications in older Asian patients with schizophrenia, 2001–2009

  • Yu-Tao Xiang (a1) (a2), Faith Dickerson (a3), Julie Kreyenbuhl (a4) (a5), Gabor S. Ungvari (a6), Chuan-Yue Wang (a2), Tian-Mei Si (a7), Edwin H. M. Lee (a1), Yan-Ling He (a8), Helen F. K. Chiu (a1), Kelly Y. C. Lai (a1), Naotaka Shinfuku (a9), Shu-Yu Yang (a10), Mian-Yoon Chong (a11), Ee-Heok Kua (a12), Senta Fujii (a13), Kang Sim (a14), Michael K. H. Yong (a14), Jitendra K. Trivedi (a15), Eun-Kee Chung (a16), Pichet Udomratn (a17), Kok-Yoon Chee (a18), Norman Sartorius (a19) and Chay-Hoon Tan (a12)...

Abstract

Background: This study examined the use of low doses of antipsychotic medications (300 mg/day CPZeq or less) in older Asian patients with schizophrenia and its demographic and clinical correlates.

Methods: Information on hospitalized patients with schizophrenia, aged 55 years or older, was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001–2009). Data on 1,452 patients in eight Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India, and Malaysia were analyzed. Sociodemographic and clinical characteristics and antipsychotic prescriptions were recorded using a standardized protocol and data collection procedure.

Results: The prescription frequency for low doses of antipsychotic medications was 40.9% in the pooled sample. Multiple logistic regression analysis of the whole sample showed that patients on low doses of antipsychotic medications were more likely to be female, have an older age, a shorter length of illness, and less positive symptoms. Of patients in the six countries and territories that participated in all the surveys between 2001 and 2009, those in Japan were less likely to receive low doses of antipsychotics.

Conclusion: Low doses of antipsychotic medications were only applied in less than half of older Asian patients with schizophrenia.

Copyright

Corresponding author

Correspondence should be addressed to: Dr. Yu-Tao Xiang, Department of Psychiatry, Chinese University of Hong Kong, Ground Floor, Multicentre, Tai Po Hospital, Tai Po, N.T., Hong Kong. Phone: +852-2607-6041; Fax: +852-2647-5321. Email: xyutly@gmail.com.
Dr. Tian-Mei Si, Peking University Institute of Mental Health, Beijing, China. Email: si.tian-mei@163.com.

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