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Mini-mental State Examination performance in mild cognitive impairment subtypes

  • Breno S. O. Diniz (a1), Monica S. Yassuda (a1), Paula V. Nunes (a1), Marcia Radanovic (a1) and Orestes V. Forlenza (a1)...

Abstract

Background: Diagnosis of mild cognitive impairment (MCI) and its subtypes requires a detailed diagnostic assessment and so may be missed at routine primary-care appointments, since the ordinary dementia screening tests lack sensitivity owing to ceiling effects, especially in highly educated subjects.

Methods: The study was undertaken using a cross-sectional assessment of 112 elderly subjects (mean age 67.96 ± 5.77 years, and mean education level of 12.8 ± 5.7 years) with a semi-structured interview and a neuropsychological battery.

Results: MCI patients did not differ from controls on total MMSE scores (p = 0.212). Nevertheless, MCI patients showed worse performance than controls on the verbal memory task (p = 0.012), and “drawing a pentagon” (p = 0.03). Amnestic MCI patients performed worse only on the “three-word recall” task (p = 0.013); non-amnestic MCI patients performed worse on the “three-stage command” task (p = 0.001); and multiple-domain MCI patients performed worse on the “drawing a pentagon” task (p = 0.001) and had a trend toward performing poorly on the ‘three word recall’ task (p = 0.06).

Conclusion: The analysis of MMSE subtest scores, in addition to MMSE total scores, may increase the sensitivity of the MMSE test in screening for MCI and its subtypes.

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Corresponding author

Correspondence should be addressed to: Dr. Orestes V. Forlenza, Laboratory of Neuroscience – LIM 27, Institute of Psychiatry, University of São Paulo, Rua Ovidio Pires de Campos, 785. Cerqueira César, São Paulo, Brazil, CEP 05403–010. Phone: +55 11 3069 7924; Fax: +55 11 3069 7924. Email: forlenza@usp.br.

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Mini-mental State Examination performance in mild cognitive impairment subtypes

  • Breno S. O. Diniz (a1), Monica S. Yassuda (a1), Paula V. Nunes (a1), Marcia Radanovic (a1) and Orestes V. Forlenza (a1)...

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