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Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people

  • Shih-Wei Lai (a1) (a2), Cheng-Li Lin (a1) (a3) and Kuan-Fu Liao (a4) (a5) (a6)

Abstract

Background:

The purpose of this paper was to examine whether glaucoma could be a non-memory manifestation of Alzheimer's disease in older people.

Methods:

We conducted a population-based, retrospective, case-control study to analyze the database of the Taiwan National Health Insurance Program. There were 1,351 subjects ≥65 years old with newly diagnosed Alzheimer's disease as the cases, and 5,329 subjects without any type of dementias as the controls during 2000–2011. The odds ratio (OR) and 95% confidence interval (CI) for the risk of Alzheimer's disease associated with glaucoma was estimated by the multivariable unconditional logistic regression model.

Results:

After controlling for confounders, the multivariable logistic regression model demonstrated that the adjusted OR of Alzheimer's disease was 1.50 in subjects with glaucoma (95% CI 1.19, 1.89), compared to subjects without glaucoma.

Conclusions:

Older people with glaucoma are associated with 1.5-fold increased odds of Alzheimer's disease in Taiwan. Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people. Further research is needed to confirm this issue.

Copyright

Corresponding author

Correspondence should be addressed to: Kuan-Fu Liao, Department of Internal Medicine, Taichung Tzu Chi General Hospital, No.66, Sec. 1, Fongsing Road, Tanzi District, Taichung City, 427, Taiwan. Phone: +886-4-2205-2121; Fax: 886-4-2203-3986. Email: kuanfuliaog@gmail.com

References

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Albers, M. W. et al. (2015). At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimers Dement, 11, 7098.
Arshavsky, Y. I. (2010). Why Alzheimer's disease starts with a memory impairment: neurophysiological insight. Journal of Alzheimers Disease, 20, 516.
Bayer, A. U., Ferrari, F. and Erb, C. (2002). High occurrence rate of glaucoma among patients with Alzheimer's disease. European Neurology, 47, 165168.
Chen, H. Y., Lin, C. L., Lai, S. W. and Kao, C. H. (2016). Association of selective serotonin reuptake inhibitor use and acute angle-closure glaucoma. Journal of Clinical Psychiatry, 77, e692–e696.
Chrysostomou, V., Rezania, F., Trounce, I. A. and Crowston, J. G. (2013). Oxidative stress and mitochondrial dysfunction in glaucoma. Current Opinion in Pharmacology, 13, 1215.
Flynn, J. M. and Melov, S. (2013). SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radical Biology Medicine, 62, 412.
Fukuoka, H. and Afshari, N. A. (2017). The impact of age-related cataract on measures of frailty in an aging global population. Current Opinion in Ophthalmology, 28, 9397.
Ghiso, J. A., Doudevski, I., Ritch, R. and Rostagno, A. A. (2013). Alzheimer's disease and glaucoma: mechanistic similarities and differences. Journal of Glaucoma, 22, 3638.
Hroudova, J., Singh, N. and Fisar, Z. (2014). Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease. Biomed Research International, 175062, 12.
Hsu, F.-G., Sheu, M.-J., Lin, C.-L., Hsieh, Y.-W. and Lai, S.-W. (2017). Use of zolpidem and risk of acute pyelonephritis in women: a population-based case-control study in Taiwan. The Journal of Clinical Pharmacology, 57, 376381.
Hung, S. C. et al. (2013). Synergistic interaction of benign prostatic hyperplasia and prostatitis on prostate cancer risk. British Journal of Cancer, 108, 17781783.
Hung, S. C., Liao, K. F., Muo, C. H., Lai, S. W., Chang, C. W. and Hung, H. C. (2015). Hearing loss is associated with risk of Alzheimer's disease: a case-control study in older people. Journal of Epidemiology, 25, 517521.
Hung, S. C., Lin, C. H., Hung, H. C., Lin, C. L. and Lai, S. W. (2017). Use of selective serotonin reuptake inhibitors and risk of hip fracture in the elderly: a case-control study in Taiwan. Journal of the American Medical Directors Association, 18, 350354.
Hung, Y. N. et al. (2016). The epidemiology and burden of Alzheimer's disease in Taiwan utilizing data from the national health insurance research database. ClinicoEconomics and Outcomes Research, 8, 387395.
Javaid, F. Z., Brenton, J., Guo, L. and Cordeiro, M. F. (2016). Visual and ocular manifestations of Alzheimer's disease and their use as Biomarkers for diagnosis and progression. Frontiers in Neurology, 7, 55.
Klein, B. E., Klein, R. and Knudtson, M. D. (2006). Frailty and age-related cataract. Ophthalmology, 113, 22092212.
Kong, G. Y., Van Bergen, N. J., Trounce, I. A. and Crowston, J. G. (2009). Mitochondrial dysfunction and glaucoma. Journal of Glaucoma, 18, 93100.
Lai, S. W., Chen, H. J., Lin, C. L. and Liao, K. F. (2014a). No correlation between Alzheimer's disease and risk of hepatocellular carcinoma in older people: an observation in Taiwan. Geriatrics and Gerontology International, 14, 231232. doi: 10.1111/ggi.12141.
Lai, S. W., Chen, Y. L., Lin, C. L. and Liao, K. F. (2013a). Alzheimer's disease correlates with greater risk of hip fracture in older people: a cohort in Taiwan. Journal of the American Geriatrics Society, 61, 12311232. doi: 10.1111/jgs.12349.
Lai, S. W., Liao, K. F., Liao, C. C., Muo, C. H., Liu, C. S. and Sung, F. C. (2010). Polypharmacy correlates with increased risk for hip fracture in the elderly: a population-based study. Medicine, 89, 295299.
Lai, S. W., Lin, C. L. and Liao, K. F. (2013b). No association between gout and Alzheimer's disease: results of a case-control study in older people in Taiwan. International Journal of Geriatric Psychiatry, 28, 12051206. doi: 10.1002/gps.3963.
Lai, S. W., Lin, C. L. and Liao, K. F. (2014b). Cataract may be a non-memory feature of Alzheimer's disease in older people. European Journal of Epidemiology, 29, 405409.
Le, A., Mukesh, B. N., McCarty, C. A. and Taylor, H. R. (2003). Risk factors associated with the incidence of open-angle glaucoma: the visual impairment project. Investigative Ophthalmology & Visual Science, 44, 37833789.
Lee, S. et al. (2011). Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies. Experimental Eye Research, 93, 204212.
Liao, K. F., Cheng, K. C., Lin, C. L. and Lai, S. W. (2017a). Etodolac and the risk of acute pancreatitis. Biomedicine-Taiwan, 7, 2529.
Liao, K. F., Cheng, K. C., Lin, C. L. and Lai, S. W. (2017b). Statin use correlates with reduced risk of pyogenic liver abscess: a population-based case-control study. Basic & Clinical Pharmacology & Toxicology, 8, 12777.
Liao, K. F., Lai, S. W., Li, C. I. and Chen, W. C. (2012). Diabetes mellitus correlates with increased risk of pancreatic cancer: a population-based cohort study in Taiwan. Journal of Gastroenterology and Hepatology, 27, 709713.
Lin, C. M., Liao, K. F., Lin, C. L. and Lai, S. W. (2017). Use of simvastatin and risk of acute pancreatitis: a nationwide case-control study in Taiwan. Journal of Clinical Pharmacology, 16, 881.
Mendez, M. F., Lee, A. S., Joshi, A. and Shapira, J. S. (2012). Nonamnestic presentations of early-onset Alzheimer's disease. American Journal of Alzheimers Disease & Other Dementias, 27, 413420.
National Health Insurance Research Database, Taiwan. ([Cited in April 1, 2017, English version]). http://nhird.nhri.org.tw/en/index.html.
Onyango, I. G. and Khan, S. M. (2006). Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease. Current Alzheimer Research, 3, 339349.
Pal, S., Sanyal, D., Biswas, A., Paul, N. and Das, S. K. (2013). Visual manifestations in Alzheimer's disease: a clinic-based study from India. American Journal of Alzheimers Disease & Other Demenias, 28, 575582.
Panza, F. et al. (2015a). Targeting cognitive frailty: clinical and neurobiological roadmap for a single complex phenotype. Journal of Alzheimers Disease, 47, 793813.
Panza, F. et al. (2015c). Age-related hearing impairment and frailty in Alzheimer's disease: interconnected associations and mechanisms. Frontiers in Aging Neuroscience, 7, 113.
Panza, F., Solfrizzi, V. and Logroscino, G. (2015b). Age-related hearing impairment-a risk factor and frailty marker for dementia and AD. Nature Reviews Neurology, 11, 166175.
Pelletier, A. A. et al. (2014). Prevalence of glaucoma in hospitalized older adults with Alzheimer's disease. Canadian Journal of Neurological Sciences, 41, 206209.
Rego, A. C. and Oliveira, C. R. (2003). Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochemical Research, 28, 15631574.
Shen, M. L., Liao, K. F., Tsai, S. M., Lin, C. L. and Lai, S. W. (2016). Herpes zoster correlates with pyogenic liver abscesses in Taiwan. Biomedicine, 6, 2429.
Suzuki, Y. et al. (2006). Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study. Ophthalmology, 113, 16131617.
Tham, Y. C., Li, X., Wong, T. Y., Quigley, H. A., Aung, T. and Cheng, C. Y. (2014). Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology, 121, 20812090.
Tsai, T. Y. et al. (2016). The association between biliary tract inflammation and risk of digestive system cancers: a population-based cohort study. Medicine, 95, e4427.
Tsolaki, F. et al. (2011). Alzheimer's disease and primary open-angle glaucoma: is there a connection? Clinical Ophthalmology, 5, 887890.
Valenti, D. A. (2011). Alzheimer's disease and glaucoma: imaging the biomarkers of neurodegenerative disease. International Journal of Alzheimers Disease, 5, 793931.
Wong, T. S., Liao, K. F., Lin, C. M., Lin, C. L., Chen, W. C. and Lai, S. W. (2016). Chronic pancreatitis correlates with increased risk of cerebrovascular disease: a retrospective population-based cohort study in Taiwan. Medicine, 95, e3266.
Yang, S. P. et al. (2015). Risk of type 2 diabetes mellitus in female breast cancer patients treated with morphine: a retrospective population-based time-dependent cohort study. Diabetes Research and Clinical Practice, 110, 285290.

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