Skip to main content Accessibility help
×
Home

The Effect of a Single Low Dose of Trihexyphenidyl on Memory Functioning in the Healthy Elderly

  • Bharat Raj S. Nakra (a1) (a2), Ronald B. Margolis (a1), Jeffrey D. Gfeller (a1), George T. Grossberg (a1) and Lindbergh S. Sata (a1)...

Abstract

Medications with anticholinergic properties, when taken at therapeutic doses, are known to adversely affect memory functioning in young adults and the elderly. However, their impact at lower doses in geriatric persons has been less thoroughly studied. We investigated the impact of a single 2-mg dose of trihexyphenidyl on memory functioning in 20 healthy elderly subjects using a within-subjects, double-blind comparison with a placebo. Memory functioning was evaluated using subtests of the Wechsler Memory Scale. Subjects also rated the perceived impact of medication on their performance following memory testing.

Results indicated that the single 2-mg dose of trihexyphenidyl produced impaired performance on measures of immediate and half-hour delayed recall of complex verbal and visual material when compared to the placebo condition. However, differences were not found on several other memory measures, including general orientation, attention-concentration, and learning of word associations. The significance of these selective memory deficits and suggestions regarding future research are discussed.

Copyright

Related content

Powered by UNSILO

The Effect of a Single Low Dose of Trihexyphenidyl on Memory Functioning in the Healthy Elderly

  • Bharat Raj S. Nakra (a1) (a2), Ronald B. Margolis (a1), Jeffrey D. Gfeller (a1), George T. Grossberg (a1) and Lindbergh S. Sata (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.