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Does past or present depression differentiate Lewy body from Alzheimer disease?

  • Jed Falkowski (a1), Linda S. Hynan (a1) (a2) (a3), Kyle B. Womack (a3) (a4), Kimmo J. Hatanpaa (a3) (a5), Charles L. White (a3) (a5) and Myron F. Weiner (a1)...

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Clinical differentiation of Lewy body disease (LBD) from Alzheimer disease (AD) is still problematic. Many persons with LBD lack the cardinal features of visual hallucinations, fluctuations in cognition, and mild Parkinsonism proposed by McKeith et al. (2005). Some studies suggest that history or presence of depression may help distinguish LBD from AD, but this is confounded because many clinically diagnosed LBD patients have significant co-morbid AD pathology and vice versa (Ranginwala et al., 2008). We aimed to clarify whether history or symptoms of depression differentiate LBD from AD, in autopsy-confirmed patients, excluding patients with mixed AD and LBD pathology.

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References

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Boot, B. P. et al. (2013). Risk factors for dementia with Lewy bodies: a case-control study. Neurology, 81, 833840.
Klatka, L. A., Louis, E. D. and Schiffer, R. B. (1996). Psychiatric features in diffuse Lewy body disease: a clinicopathologic study using Alzheimer's disease and Parkinson's disease comparison groups. Neurology, 47, 11481152.
McKeith, I. G. et al. (2005). Diagnosis and management of dementia with Lewy bodies third report of the DLB consortium. Neurology, 65, 18631872.
Ranginwala, N. A. et al. (2008). Clinical criteria for the diagnosis of Alzheimer disease: still good after all these years. The American Journal of Geriatric Psychiatry, 16, 384388.

Does past or present depression differentiate Lewy body from Alzheimer disease?

  • Jed Falkowski (a1), Linda S. Hynan (a1) (a2) (a3), Kyle B. Womack (a3) (a4), Kimmo J. Hatanpaa (a3) (a5), Charles L. White (a3) (a5) and Myron F. Weiner (a1)...

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