Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-25T04:58:11.204Z Has data issue: false hasContentIssue false
  • English
  • Français

Describing Cognitive Decline of Patients at the Mild or Moderate Stages of Alzheimer's Disease Using the Standardized MMSE

Published online by Cambridge University Press:  10 January 2005

Alexandra Ward ,
J. Jaime Caro ,
Heather Kelley ,
Andrew Eggleston  and
William Molloy
Alexandra Ward
Affiliation:
Caro Research Institute, Concord, Massachusetts, US
J. Jaime Caro
Affiliation:
Caro Research Institute, Concord, Massachusetts, US
Heather Kelley
Affiliation:
Caro Research Institute, Concord, Massachusetts, US
Andrew Eggleston
Affiliation:
Janssen-Ortho, Toronto, Canada
William Molloy
Affiliation:
Geriatric Research Group, McMaster University, Hamilton, Canada.
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective: To describe the progression of patients with mild or moderate Alzheimer's disease (AD) to a severe stage using the Standardized Mini-Mental State Examination (SMMSE). Methods: A cohort of 206 patients was stratified according to their baseline SMMSE scores: mild (19–24) and moderate (10–18). Proportional hazards analyses were used to determine the hazard of switching into a severe stage, defined as SMMSE score < 10. Results: Among patients at the mild stage, 25% reached the severe stage within 2.6 years, and in the moderate group within 1.5 years. Patients with hallucinations at the mild stage experienced more rapid decline. The previous rate of decline was also found to be an important predictor. At the moderate stage, key predictors were lower SMMSE score and longer time since onset. Conclusions: Current SMMSE scores with other clinical details can be used to advise patients and caregivers about the expected progression of AD.

Keywords

Standardized MMSEprogressionpredictionAlzheimer's diseasecongnition
Type
Articles
Information
International Psychogeriatrics , Volume 14 , Issue 3 , September 2002 , pp. 249 - 258
Copyright
© 2002 International Psychogeriatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)