Skip to main content Accessibility help
×
Home

Changes in mild cognitive impairment and its subtypes as seen on diffusion tensor imaging

  • Senthil Thillainadesan (a1), Wei Wen (a1), Lin Zhuang (a1), John Crawford (a1), Nicole Kochan (a1), Simone Reppermund (a1), Melissa Slavin (a1) (a2), Julian Trollor (a3), Henry Brodaty (a2) (a4) and Perminder Sachdev (a1) (a5)...

Abstract

Background: Previous studies using diffusion tensor imaging (DTI) have observed microstructural abnormalities in white matter regions in both Alzheimer's disease and mild cognitive impairment (MCI). The aim of this work was to examine the abnormalities in white matter and subcortical regions of MCI and its subtypes in a large, community-dwelling older aged cohort

Methods: A community-based sample of 396 individuals without dementia underwent medical assessment, neuropsychiatric testing, and neuroimaging. Of these, 158 subjects were classified as MCI and 238 as cognitively normal (controls) based on international MCI consensus criteria. Regional fractional anisotropy (FA) and mean diffusivity (MD) measures were calculated from the DTI and compared between groups. The false discovery rate correction was applied for multiple testing.

Results: Subjects with MCI did not have significant differences in FA compared with controls after correction for multiple testing, but had increased MD in the right putamen, right anterior limb of the internal capsule, genu and splenium of the corpus callosum, right posterior cingulate gyrus, left superior frontal gyrus, and right and left corona radiata. When compared with controls, changes in left anterior cingulate, left superior frontal gyrus, and right corona radiata were associated with amnestic MCI (aMCI), whereas changes in the right putamen, right anterior limb of the internal capsule, and the right corona radiata were associated with non-amnestic MCI (naMCI). On logistic regression, the FA values in the left superior gyrus and MD values in the anterior cingulate distinguished aMCI from naMCI.

Conclusions: MCI is associated with changes in white matter and subcortical regions as seen on DTI. Changes in some anterior brain regions distinguish aMCI from naMCI.

Copyright

Corresponding author

Correspondence should be addressed to: Professor Perminder Sachdev, Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, NSW 2031, Australia. Phone: +61 2 9382 3763; Fax: +61 2 93823774. Email: p.sachdev@unsw.edu.au.

References

Hide All
Benton, A. (1967). Problems of test construction in the field of aphasia. Cortex, 3, 3258.
Benton, A., Sivan, A. and Spreen, O. (1996). Der Benton-Test. Handbuch. Bern: Hans Huber.
Busse, A., Hensel, A., Guhne, U., Angermeyer, M. and Riedel-Heller, S. (2006). Mild cognitive impairment: long-term course of four clinical subtypes. Neurology, 67, 21762185. doi: 10.1212/01.WNL.0000249117.23318.e1.
DeCarli, C. (2003). Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment. Lancet Neurology, 2, 1521. doi: 10.1016/S1474-4422(03)00262-X.
Di Paola, M. et al. (2010). When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study. Neurology, 74, 11361142. doi: 10.1212/WNL.0b013e3181d7d8cb.
Fellgiebel, A. et al. (2004). Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study. Dementia and Geriatriatric Cognitive Disorders, 18, 101108. doi: 10.1159/000077817.
Fellgiebel, A. et al. (2005). Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment. Neurobiology of Aging, 26, 11931198. doi: 10.1016/j.neurobiolaging.2004.11.006.
Fischer, P. et al. (2007). Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology, 68, 288291. doi: 10.1212/01.wnl.0000252358.03285.9d.
Giannelli, M. et al. (2009). Dependence of brain DTI maps of fractional anisotropy and mean diffusivity on the number of diffusion weighting directions. Journal of Applied Clinical Medical Physics, 11, 2927.
He, J., Farias, S., Martinez, O., Reed, B., Mungas, D. and Decarli, C. (2009). Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes. Archives of Neurology, 66, 13931399.
Hindmarch, I., Lehfeld, H., de Jongh, P. and Erzigkeit, H. (1998). The Bayer Activities of Daily Living Scale (B-ADL). Dementia and Geriatric Cognitive Disorders, 9 (Suppl. 2), 2026. doi: 10.1159/000051195.
Huang, J., Friedland, R. P. and Auchus, A. P. (2007). Diffusion tensor imaging of normal-appearing white matter in mild cognitive impairment and early Alzheimer disease: preliminary evidence of axonal degeneration in the temporal lobe. American Journal of Neuroradiology, 28, 19431948. doi: 10.3174/ajnr.A0700.
Kantarci, K. et al. (2008). Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes. Archives of Neurology, 65, 16211628.
Kaplan, E., Goodglass, H. and Weintraub, S. (2001). Boston Naming Test. Baltimore, MD: Lippincott Williams and Wilkins.
Lawton, M. P. and Brody, E. M. (1969). Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 9, 179186.
Lee, D. Y. et al. (2009). Regional pattern of white matter microstructural changes in normal aging, MCI, and AD. Neurology, 73, 17221728. doi: 10.1212/WNL.0b013e3181c33afb.
Luchsinger, J. A. et al. (2009). Subclinical cerebrovascular disease in mild cognitive impairment. Neurology, 73, 450456. doi: 10.1212/WNL.0b013e3181b1636a.
Mariani, E. et al. (2007a). Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project. Dementia and Geriatric Cognitive Disorders, 24, 448456. doi: 10.1159/000110653.
Mariani, E., Monastero, R. and Mecocci, P. (2007b). Mild cognitive impairment: a systematic review. Journal of Alzheimer's Disease, 12, 2335.
Medina, D. et al. (2006). White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study. Neurobiology of Aging, 27, 663672. doi: 10.1016/j.neurobiolaging.2005.03.026.
Mielke, M. M. et al. (2009). Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neuroimage, 46, 4755.
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194. doi: 10.1111/j.1365-2796.2004.01388.x.
Petersen, R. C. et al. (2009). Mild cognitive impairment: ten years later. Archives of Neurology, 66, 14471455.
Reitan, R. and Wolfson, D. (1993). The Halstead–Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Tucson, AZ: Neuropsychology Press.
Rey, A. (1964). L'Examen Clinique En Psychologie [The Clinical Examination in Psychology]. Paris: Presses Universitaires de France.
Sachdev, P. et al. (2010). The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70–90. International Psychogeriatrics, 22, 12481264. doi: 10.1017/S1041610210001067.
Shim, Y. S., Yoon, B., Shon, Y.-M., Ahn, K.-J. and Yang, D.-W. (2008). Difference of the hippocampal and white matter microalterations in MCI patients according to the severity of subcortical vascular changes: neuropsychological correlates of diffusion tensor imaging. Clinical Neurology and Neurosurgery, 110, 552561. doi: 10.1016/j.clineuro.2008.02.021.
Smith, S. M. et al. (2004). Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage, 23 (Suppl. 1), S208S219.
Spreen, O. and Benton, A. (1969). Neurosensory Centre Comprehensive Examination for Aphasia. Victoria, BC, Canada: University of Victoria.
van de Pol, L. A. et al. (2009). White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study. Journal of Neurology, Neurosurgery and Psychiatry, 80, 10691074. doi: 10.1136/jnnp.2008.158881.
Wechsler, D. (1981). Wais-R Manual. New York: The Psychological Corporation.
Wechsler, D. (1997a). Wechsler Adult Intelligence Scale-III. San Antonio, TX: The Psychological Corporation.
Wechsler, D. (1997b.) Wechsler Memory Scale, Manual. 3rd edn. San Antonio, TX: The Psychological Corporation.
Whitwell, J. L. et al. (2007). Patterns of atrophy differ among specific subtypes of mild cognitive impairment. Archives of Neurology, 64, 11301138.
Winblad, B. et al. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240246. doi: 10.1111/j.1365-2796.2004.01380.x.
Xie, S. et al. (2006). Voxel-based detection of white matter abnormalities in mild Alzheimer disease. Neurology, 66, 18451849. doi: 10.1212/01.wnl.0000219625.77625.aa.
Yaffe, K., Petersen, R. C., Lindquist, K., Kramer, J. and Miller, B. (2006). Subtype of mild cognitive impairment and progression to dementia and death. Dementia and Geriatric Cognitive Disorders, 22, 312319. doi: 10.1159/000095427.
Zhang, Y. et al. (2007). Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology, 68, 1319. doi: 10.1212/01.wnl.0000250326.77323.01.

Keywords

Related content

Powered by UNSILO

Changes in mild cognitive impairment and its subtypes as seen on diffusion tensor imaging

  • Senthil Thillainadesan (a1), Wei Wen (a1), Lin Zhuang (a1), John Crawford (a1), Nicole Kochan (a1), Simone Reppermund (a1), Melissa Slavin (a1) (a2), Julian Trollor (a3), Henry Brodaty (a2) (a4) and Perminder Sachdev (a1) (a5)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.