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Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample

Published online by Cambridge University Press:  24 September 2004

Dylan G. Harwood ,
Warren W. Barker ,
Raymond L. Ownby ,
Peter St. George-Hyslop ,
Michael Mullan  and
Ranjan Duara
Dylan G. Harwood
Affiliation:
Neuropsychiatric Institute and Hospital, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center and University of Miami School of Medicine
Warren W. Barker
Affiliation:
The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center and University of Miami School of Medicine
Raymond L. Ownby
Affiliation:
The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center and University of Miami School of Medicine Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine
Peter St. George-Hyslop
Affiliation:
Departments of Medicine and Physiology, Center for Research in Neurodegenerative Diseases, University of Toronto
Michael Mullan
Affiliation:
Roskamp Laboratory, Department of Psychiatry, University of South Florida
Ranjan Duara
Affiliation:
The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center and University of Miami School of Medicine Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine Department of Medicine, University of Miami School of Medicine
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Abstract

Objective: This study examined the association between the Apolipoprotein-E ε4 allele (APOE ε4) and age of disease onset in a bi-ethnic sample of community dwelling Alzheimer's disease (AD) patients.

Design: Cross-sectional study of AD patients evaluated at a University-affiliated outpatient memory disorders clinic.

Subjects: A clinic-based cohort of white non-Hispanic (WNH; n=601) and white Hispanic (WH; n=359) patients diagnosed with possible or probable AD according to NINCDS-ADRDA diagnostic criteria.

Measures: Global cognitive functioning of the subjects was evaluated using the Mini-mental State Exam. The age of onset of AD was calculated from the patient's current age minus the reported duration of disease obtained from a knowledgeable family member.

Results: A significant relationship was discovered between APOE ε4 and age of onset for WNH, with lower ages of onset among patients carrying the ε4/ε4 and ε3˜/ε4 genotypes in relation to patients with the ε3/ε3 genotype. The results revealed a more modest effect for APOE genotype in the WH cohort, with a lower age of onset witnessed among ε4 positive patients (ε2/ε4, ε3/ε4 and ε4/ε4 genotypes) in comparison to ε4 negative patients (ε2/ε2, ε2/ε3 and ε3/ε3 genotypes).

Conclusion: The association between the ε4 allele and earlier age of onset was more pronounced in WNH compared to WH patients, suggesting the impact of APOE polymorphism on clinical phenotype may be different for distinct ethnic groups in the U.S.

Type
Research Article
Information
International Psychogeriatrics , Volume 16 , Issue 3 , September 2004 , pp. 317 - 326
Copyright
© International Psychogeriatric Association 2004

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