Hostname: page-component-77c89778f8-swr86 Total loading time: 0 Render date: 2024-07-25T03:51:54.698Z Has data issue: false hasContentIssue false

Caregiver burden, sleep quality, depression, and anxiety in dementia caregivers: a comparison of frontotemporal lobar degeneration, dementia with Lewy bodies, and Alzheimer's disease

Published online by Cambridge University Press:  10 December 2017

Shuai Liu
Affiliation:
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China
Jing Liu
Affiliation:
Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Hebei Province, China
Xiao-Dan Wang
Affiliation:
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China
Zhihong Shi
Affiliation:
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China
Yuying Zhou
Affiliation:
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China
Jing Li
Affiliation:
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China
Tao Yu
Affiliation:
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Yong Ji*
Affiliation:
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China
*
Correspondence should be addressed to: Yong Ji, MD, PhD, Department of Neurology, Tianjin Huanhu Hospital, Tianjin Dementia Institute, 6 Jizhao Road, Jinnan District, Tianjin, 300350, China. Phone: +8622 59065149. Email: jiyongusa@126.com.

Abstract

Background:

Very few recent studies are available that compare caregiver burden, sleep quality, and stress in caregivers of different types of dementia. We aimed to investigate caregiver burden, sleep quality, and stress in caregivers of patients with frontotemporal lobar degeneration and dementia with Lewy bodies, as compared with caregivers of patients with Alzheimer's disease.

Methods:

This study was carried out from March 2011 to January 2014. In total, 492 dyads of patient and caregiver (frontotemporal lobar degeneration, n = 131; dementia with Lewy bodies, n = 36; Alzheimer's disease, n = 325) participated in this study. We compared patients with respect to the Neuropsychiatric Inventory and caregivers with respect to the Zarit Caregiver Burden Interview, Pittsburgh Sleep Quality Index, Patient Health Questionnaire-9, and Generalized Anxiety Disorder scale.

Results:

Frontotemporal lobar degeneration and dementia with Lewy bodies patients presented significantly more neuropsychiatric symptoms compared to Alzheimer's disease patients. Caregivers of frontotemporal lobar degeneration and dementia with Lewy bodies patients experienced significantly more burden compared to Alzheimer's disease caregivers. Furthermore, among caregivers of both frontotemporal lobar degeneration and dementia with Lewy bodies patients burden was predicted by the neuropsychiatric symptoms, PHQ-9 scores, and GAD-7 scores.

Conclusions:

The frequency and severity of behavioral disturbances in patient and caregiver stress accounted for the increased caregiver burden, which suggests that frontotemporal lobar degeneration and dementia with Lewy bodies caregivers should receive more support than is currently available.

Type
Original Research Article
Copyright
Copyright © International Psychogeriatric Association 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

#

These authors contributed equally to this work.

References

Bjoerke-Bertheussen, J., Ehrt, U., Rongve, A., Ballard, C. and Aarsland, D. (2012). Neuropsychiatric symptoms in mild dementia with Lewy bodies and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 34, 16.Google Scholar
Bocquet, H., Pous, J., Charlet, J. P. and Grand, A. (1996). Measuring the burden for carers of dependent elderly with the Zarit inventory. Rev Epidemiol Sante Publique, 44, 5765.Google Scholar
Boutoleau-Bretonniere, C., Vercelletto, M., Volteau, C., Renou, P. and Lamy, E. (2008). Zarit burden inventory and activities of daily living in the behavioral variant of frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 25, 272277.Google Scholar
Bozeat, S., Gregory, C. A., Ralph, M. A. and Hodges, J. R. (2000). Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? Journal of Neurology, Neurosurgery, and Psychiatry, 69, 178186.Google Scholar
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R. and Kupfer, D. J. (1989). The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Research, 28, 193213.Google Scholar
Caceres, B. A., Frank, M. O., Jun, J., Martelly, M. T., Sadarangani, T. and de Sales, P. C. (2016). Family caregivers of patients with frontotemporal dementia: an integrative review. International Journal of Nursing Studies, 55, 7184.Google Scholar
Cohen, S., Kamarck, T. and Mermelstein, R. (1983). A global measure of perceived stress. Journal of Health and Social Behavior, 24, 385396.Google Scholar
Collerton, D., Burn, D., McKeith, I. and O'Brien, J. (2003). Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dementia and Geriatric Cognitive Disorders, 16, 229237.Google Scholar
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A. and Gornbein, J. (1994). The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology, 44, 23082314.Google Scholar
de Vugt, M. E., Riedijk, S. R., Aalten, P., Tibben, A., van Swieten, J. C. and Verhey, F. R. (2006). Impact of behavioural problems on spousal caregivers: a comparison between Alzheimer's disease and frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 22, 3541.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.Google Scholar
Hodges, J. R. (2001). Frontotemporal dementia (Pick's disease): clinical features and assessment. Neurology, 56, S6–10.Google Scholar
Joshi, A., Barsuglia, J. P., Mather, M. J., Jimenez, E. E., Shapira, J. and Mendez, M. F. (2014). Evaluation of emotional blunting in behavioral variant frontotemporal dementia compared to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 38, 7988.Google Scholar
Katz, S., Ford, A. B., Moskowitz, R. W., Jackson, B. A. and Jaffe, M. W. (1963). Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA, 185, 914919.Google Scholar
Kroenke, K., Spitzer, R. L. and Williams, J. B. (2001). The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 16, 606613.Google Scholar
Levy, M. L., Miller, B. L., Cummings, J. L., Fairbanks, L. A. and Craig, A. (1996). Alzheimer disease and frontotemporal dementias. Behavioral distinctions. Archives of Neurology, 53, 687690.Google Scholar
Lima-Silva, T. B. et al. (2015). Neuropsychiatric symptoms, caregiver burden and distress in behavioral-variant frontotemporal dementia and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 40, 268275.Google Scholar
McKeith, I. G. et al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology, 47, 11131124.Google Scholar
McKeith, I. G. et al. (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology, 65, 18631872.Google Scholar
Merrilees, J. (2007). A model for management of behavioral symptoms in frontotemporal lobar degeneration. Alzheimer Disease and Associated Disorders, 21, S64–69.Google Scholar
Metzler-Baddeley, C. (2007). A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia. Cortex, 43, 583600.Google Scholar
Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A. and Hodges, J. R. (2007). Activities of daily living in frontotemporal dementia and Alzheimer disease. Neurology, 68, 20772084.Google Scholar
Mrak, R. E. and Griffin, W. S. (2007). Dementia with Lewy bodies: definition, diagnosis, and pathogenic relationship to Alzheimer's disease. Neuropsychiatric Disease and Treatment, 3, 619625.Google Scholar
Neary, D. et al. (1998). Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology, 51, 15461554.Google Scholar
Ricci, M. et al. (2009). Clinical findings, functional abilities and caregiver distress in the early stage of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Archives of Gerontology and Geriatrics, 49, e101e104.Google Scholar
Riedijk, S. R. et al. (2006). Caregiver burden, health-related quality of life and coping in dementia caregivers: a comparison of frontotemporal dementia and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 22, 405412.Google Scholar
Rozzini, L., Lussignoli, G., Padovani, A., Bianchetti, A. and Trabucchi, M. (1997). Alzheimer disease and frontotemporal dementia. Archives of Neurology, 54, 350.Google Scholar
Simard, M., van Reekum, R. and Cohen, T. (2000). A review of the cognitive and behavioral symptoms in dementia with Lewy bodies. The Journal of Neuropsychiatry & Clinical Neurosciences, 12, 425450.Google Scholar
Sorrell, J. M. (2013). Diagnostic and statistical manual of mental disorders-5: implications for older adults and their families. Journal of Psychosocial Nursing and Mental Health Services, 51, 1922.Google Scholar
Spitzer, R. L., Kroenke, K., Williams, J. B. and Lowe, B. (2006). A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of International Medicine, 166, 10921097.Google Scholar
Srikanth, S., Nagaraja, A. V. and Ratnavalli, E. (2005). Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular dementia and frontotemporal dementia. Journal of the Neurological Sciences, 236, 4348.Google Scholar
Svendsboe, E. et al. (2016). Caregiver burden in family carers of people with dementia with Lewy bodies and Alzheimer's disease. International Journal of Geriatric Psychiatry, 31, 10751083.Google Scholar
The Lund and Manchester Groups (1994). Clinical and neuropathological criteria for frontotemporal dementia. Journal of Neurology, Neurosurgery & Psychiatry, 57, 416418.Google Scholar
Uflacker, A., Edmondson, M. C., Onyike, C. U. and Appleby, B. S. (2016). Caregiver burden in atypical dementias: comparing frontotemporal dementia, Creutzfeldt-Jakob disease, and Alzheimer's disease. International Psychogeriatrics, 28, 269273.Google Scholar
Wong, C., Merrilees, J., Ketelle, R., Barton, C., Wallhagen, M. and Miller, B. (2012). The experience of caregiving: differences between behavioral variant of frontotemporal dementia and Alzheimer disease. The American Journal of Geriatric Psychiatry, 20, 724728.Google Scholar
Zweig, Y. R. and Galvin, J. E. (2014). Lewy body dementia: the impact on patients and caregivers. Alzheimer's Research & Therapy, 6, 21.Google Scholar