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Cost-Effectiveness of Pain Management Strategies in Advanced Cancer

  • David M. Meads (a1), John L. O'Dwyer (a1), Claire T. Hulme (a1), Rocio Rodriguez Lopez (a1) and Michael I. Bennett (a2) (a3)...

Abstract

Objectives

Uncontrolled pain in advanced cancer is a common problem and has significant impact on individuals’ quality of life and use of healthcare resources. Interventions to help manage pain at the end of life are available, but there is limited economic evidence to support their wider implementation. We conducted a case study economic evaluation of two pain self-management interventions (PainCheck and Tackling Cancer Pain Toolkit [TCPT]) compared with usual care.

Methods

We generated a decision-analytic model to facilitate the evaluation. This modelled the survival of individuals at the end of life as they moved through pain severity categories. Intervention effectiveness was based on published meta-analyses results. The evaluation was conducted from the perspective of the U.K. health service provider and reported cost per quality-adjusted life-year (QALY).

Results

PainCheck and TCPT were cheaper (respective incremental costs -GBP148 [-EUR168.53] and -GBP474 [-EUR539.74]) and more effective (respective incremental QALYs of 0.010 and 0.013) than usual care. There was a 65 percent and 99.5 percent chance of cost-effectiveness for PainCheck and TCPT, respectively. Results were relatively robust to sensitivity analyses. The most important driver of cost-effectiveness was level of pain reduction (intervention effectiveness). Although cost savings were modest per patient, these were considerable when accounting for the number of potential intervention beneficiaries.

Conclusions

Educational and monitoring/feedback interventions have the potential to be cost-effective. Economic evaluations based on estimates of effectiveness from published meta-analyses and using a decision modeling approach can support commissioning decisions and implementation of pain management strategies.

Copyright

Corresponding author

Author for correspondence: David Meads, E-mail: d.meads@leeds.ac.uk

Footnotes

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This report presents independent research commissioned by the National Institute for Health Research under its Programme Grants for Applied Research programme (“Improving the Management of Pain from Advanced Cancer in the Community (IMPACCT)” RP-PG-0610-10114). The views expressed in this report are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. The authors would like to thank the centers and patients who participated in the IMPACCT patient survey. As this study did not include primary research with patients or clinicians, ethical approval was not required. The authors would like to thank the centers and patients who participated in the IMPACCT patient survey.

Footnotes

References

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