Skip to main content Accessibility help

Wide Variability in the Use of Antimicrobial Lock Therapy and Prophylaxis among Infectious Diseases Consultants

  • Philip M. Polgreen (a1) (a2), Susan E. Beekmann (a1), Daniel J. Diekema (a1) and Robert J. Sherertz (a3)


We surveyed infectious diseases physicians to determine their practice patterns with regard to both antimicrobial lock prophylaxis and antimicrobial lock therapy. Antimicrobial lock prophylaxis is relatively uncommon; only 19% of infectious diseases physicians reported using it at least once. Although antimicrobial lock therapy is more commonly used, we found a significant variation in practice patterns.


Corresponding author

Division of Infectious Diseases, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, (


Hide All
1.Mermel, LA, Allon, M, Bouza, E, et al.Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009;49(1):145.
2.Safdar, N, Maki, DG. Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective, randomized trials. Clin Infect Dis 2006;43(4):474484.
3.van de Wetering, MD, van Woensel, JB. Prophylactic antibiotics for preventing early central venous catheter gram positive infections in oncology patients. Cochrane Database Syst Rev 2007;(1):CD003295.
4.Sanders, J, Pithie, A, Ganly, P, et al.A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. J Antimicrob Chemother 2008;62(4):809815.
5.Yahav, D, Rozen-Zvi, B, Gafter-Gvili, A, Leibovici, L, Gafter, U, Paul, M. Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials. Clin Infect Dis 2008;47(1):8393.
6. Infectious Diseases Society of America Emerging Infections Network's query: antimicrobial lock prophylaxis and treatment of catheter-related bloodstream infections. Accessed March 9, 2010.
7.Raad, I, Hanna, H, Jiang, Y, et al.Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. Antimicrob Agents Chemother 2007;51(5):16561660.
8.Fortun, J, Grill, F, Martin-Davila, P, et al.Treatment of long-term intravascular catheter-related bacteraemia with antibiotic-lock therapy. 7 Antimicrob Chemother 2006;58:816821.


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed