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The Utility of Polysporin Ointment in the Eradication of Methicillin-Resistant Staphylococcus aureus Colonization: A Pilot Study

  • Scott Fung (a1), Sharon O'Grady (a2), Catharine Kennedy (a3), Helen Dedier (a4), Iivi Campbell (a4) and John Conly (a1) (a4) (a3) (a2)...

Abstract

We evaluated the efficacy of an ointment containing bacitracin, polymyxin B, and gramicidin for the eradication of colonization by methicillin-resistant Staphylococcus aureus in 11 medical patients, 10 (91%) of whom had previously failed a 1-week course of topical mupirocin. Mupirocin resistance was documented in 5 (45%) of 11 patients. Successful decolonization was achieved in 9 (82%) of 11 patients (based on 2 months of follow-up).

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Corresponding author

Hospital Epidemiologist, University Health Network, 13 NU-118, Toronto General Hospital, 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada

References

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1. McGeer, A, Low, D, Conly, J, Campbell, I, Devlin, R, Simor, A, et al. Methicillin-resistant Staphylococcus aureus in Ontario. Can Commun Dis Rep 1997;23:4546.
2. Thomas, JC, Bridge, J, Waterman, S, Vogt, J, Kilman, L, Hancock, G. Transmission and control of methicillin-resistant Staphylococcus aureus in a skilled nursing facility. Infect Control Hosp Epidemiol 1989;10:106110.
3. Hsu, CC, Macaluso, CP, Special, L, Hubble, RH. High rate of methicillin resistance of Staphylococcus aureus isolated from hospitalized nursing home patients. Ann Intern Med 1988;148:569570.
4. Mylotte, J. Staphylococcus species. APIC Infection Control and Applied Epidemiology Principles and Practice. Mosby Inc; 1996:781–78-12.
5. Kauffman, CA, Terpenning, MS, He, X, Zarins, LT, Ramsey, MA, Jorgensen, KA, et al. Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term-care facility with the use of mupirocin ointment. Am J Med 1998;94:371378.
6. Miller, MF, Dascal, A, Portnoy, J, Mendelson, J. Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol 1996;17:811813.
7. Palepou, MF, Johnson, AP, Cookson, BD, Beattie, H, Charlett, A, Woodford, N. Evaluation of disc diffusion and Etest for determining the susceptibility of Staphylococcus aureus to mupirocin. J Antimicrob Chemother 1998;42:577583.
8. Burgess, M, Conly, J. Susceptibility of clinically significant isolates of gram-positive and gram-negative bacteria to topical antimicrobial agents. 37th ICAAC; September 1997; Toronto, Ontario, Canada. Abstract E138.
9. Cookson, BD, Lacey, RW, Noble, WC, Reeves, DS, Wise, R, Redhead, RJ. Mupirocin-resistant Staphylococcus aureus . Lancet 1990;335:10951096.
10. Netto dos Santos, KR, de Souza Fonseca, L, Gontijo Filho, PD. Emergence of high-level mupirocin resistance in methicillin-resistant Staphylococcus aureus isolated from Brazilian university hospitals. Infect Control Hosp Epidemiol 1996;17:813816.

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