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The Utility of Polysporin Ointment in the Eradication of Methicillin-Resistant Staphylococcus aureus Colonization: A Pilot Study

  • Scott Fung (a1), Sharon O'Grady (a2), Catharine Kennedy (a3), Helen Dedier (a4), Iivi Campbell (a4) and John Conly (a1) (a4) (a3) (a2)...


We evaluated the efficacy of an ointment containing bacitracin, polymyxin B, and gramicidin for the eradication of colonization by methicillin-resistant Staphylococcus aureus in 11 medical patients, 10 (91%) of whom had previously failed a 1-week course of topical mupirocin. Mupirocin resistance was documented in 5 (45%) of 11 patients. Successful decolonization was achieved in 9 (82%) of 11 patients (based on 2 months of follow-up).


Corresponding author

Hospital Epidemiologist, University Health Network, 13 NU-118, Toronto General Hospital, 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada


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