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Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

  • Kunal K. Jakharia (a1), Ghassan Ilaiwy (a1), Siobhan S. Moose (a2), Masashi Waga (a3), Lakshmi Appalla (a4), Joel D. McAlduff (a5), Lynne V. Karanfil (a6), Patrick T. McGann (a4) and Glenn W. Wortmann (a2) (a6)...


Whole-genome sequencing (WGS) has yielded new insights into the transmission patterns of healthcare facility-onset Clostridioides difficile infection (HO-CDI). WGS results prompted a focused diagnostic stewardship program, which was associated with a significant and sustained decrease in HO-CDI at large, urban hospital.


Corresponding author

Author for correspondence: Glenn W. Wortmann, Email:


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PREVIOUS PRESENTATION. Preliminary results of this work were presented at the 2018 Infectious Diseases Society of America meeting on October 4, 2018, in San Francisco, California.



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