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Trends in “usual care” for septic shock

  • Patrick S. Hume (a1), Jack Varon (a1) (a2), Joshua A. Englert (a1) (a2), Shelley Hurwitz (a1), Michael Klompas (a1) (a3), Rebecca M. Baron (a1) (a2) and Chanu Rhee (a1) (a3)...


Corresponding author

Author for correspondence: Chanu Rhee MD, MPH, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston, MA 02215. E-mail:


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1. Klompas, M, Rhee, C. The CMS sepsis mandate: right disease, wrong measure. Ann Intern Med 2016;165:517518.
2. Pepper, DJ, Jaswal, D, Sun, J, Welsh, J, Natanson, C, Eichacker, PQ. Evidence underpinning the US government-mandated hemodynamic interventions for sepsis: a systematic review. Ann Intern Med 2018;168:558568.
3. Rivers, E, Nguyen, B, Havstad, S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:13681377.
4. Peake, SL, Delaney, A, Bailey, M, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2015;371:14961506.
5. Yealy, DM, Kellum, JA, Huang, DT, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014;370:16831693.
6. Mouncey, PR, Osborn, TM, Power, GS, et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 2015;372:13011311.
7. Levy, MM.. Early goal-directed therapy: what do we do now? Crit Care 2014;18:705.
8. Castellanos-Ortega, A, Suberviola, B, Garcia-Astudillo, LA, et al. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study. Crit Care Med 2010;38:10361043.
9. Kadri, SS, Rhee, C, Strich, JR, et al. Estimating ten-year trends in septic shock incidence and mortality in United States Academic medical centers using clinical data. Chest 2017;151:278285.
10. Rhee, C, Kadri, S, Huang, SS, et al. Objective sepsis surveillance using electronic clinical data. Infect Control Hosp Epidemiol 2015;37:163171.


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