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Serologic Evaluation of MERS Screening Strategy for Healthcare Personnel During a Hospital-Associated Outbreak

  • Jae-Hoon Ko (a1), Ji Yeon Lee (a1), Jin Yang Baek (a2), Hyeri Seok (a1), Ga Eun Park (a1), Ji Yong Lee (a1), Sun Young Cho (a1), Young Eun Ha (a1), Cheol-In Kang (a1), Ji-Man Kang (a3), Yae-Jean Kim (a3), Eun-Suk Kang (a4), So Hyun Kim (a2), Ik Joon Jo (a5), Chi Ryang Chung (a6), Myong-Joon Hahn (a7), Marcel A. Müller (a8), Christian Drosten (a8) (a9), Doo Ryeon Chung (a1) (a2), Jae-Hoon Song (a1) (a2) and Kyong Ran Peck (a1)...

Abstract

To evaluate the appropriateness of the screening strategy for healthcare personnel (HCP) during a hospital-associated Middle East Respiratory Syndrome (MERS) outbreak, we performed a serologic investigation in 189 rRT-PCR–negative HCP exposed and assigned to MERS patients. Although 20%–25% of HCP experienced MERS-like symptoms, none of them showed seroconversion by plaque reduction neutralization test (PRNT).

Infect Control Hosp Epidemiol 2017;38:234–238

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Corresponding author

Address correspondence to Kyong Ran Peck, MD, PhD, Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea (krpeck@skku.edu) or to Yae-Jean Kim, MD, PhD, Division of Infectious Diseases, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 135-710, Korea; (yaejeankim@skku.edu).

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a

Authors of equal contribution.

b

Corresponding authors of equal contribution.

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References

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1. Assiri, A, McGeer, A, Perl, TM, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med 2013;369:407416.
2. Drosten, C, Meyer, B, Muller, MA, et al. Transmission of MERS-coronavirus in household contacts. N Engl J Med 2014;371:828835.
3. An Unexpected Outbreak of Middle East Respiratory Syndrome coronavirus infection in the Republic of Korea, 2015. Infect Chemother 2015;47:120–122.
4. Cho, SY, Kang, JM, Ha, YE, et al. MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study. Lancet 2016;388:9941001.
5. Park, GE, Ko, JH, Peck, KR, et al. Control of an outbreak of Middle East Respiratory Syndrome in a tertiary hospital in Korea. Ann Intern Med 2016;165:8793.
6. Management of asymptomatic persons who are RTPCR positive for Middle East respiratory syndrome coronavirus (MERS-CoV) Interim Guidance. World Health Organization website. http://www.who.int/csr/disease/coronavirus_infections/management_of_asymptomatic_patients/en/. Published 2015. Accessed January 18, 2016.
7. Muller, MA, Meyer, B, Corman, VM, et al. Presence of Middle East Respiratory Syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis 2015;15:559564.
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9. Buchholz, U, Muller, MA, Nitsche, A, et al. Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October–November 2012. Euro Surveill 2013;18 article 2.
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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