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Route of administration for antibiotics with high oral bioavailability

  • Michael J. Smith (a1), Cary Thurm (a2), Samir S. Shah (a3), Sameer J. Patel (a4), Matthew P. Kronman (a5), Jeffrey S. Gerber (a6), Joshua D. Courter (a7), Brian R. Lee (a8), Jason G. Newland (a9) and Adam L. Hersh (a10)...


Corresponding author

Author for correspondence: Michael J. Smith, MD, MSCE, Pediatric Infectious Diseases, Box 3499 Duke University Medical Center, Durham, North Carolina, 27710. E-mail:


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PREVIOUS PRESENTATION: These data were presented in part at IDWeek on October 6, 2017, in San Diego, California.

Cite this article: Smith MJ, et al. (2019). Route of administration for antibiotics with high oral bioavailability. Infection Control & Hospital Epidemiology 2019, 40, 248–249. doi: 10.1017/ice.2018.329



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1. Barlam, TF, Cosgrove, SE, Abbo, LM, et al. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 2016;62:E51E77.
2. Pediatric Health Information System (PHIS). Children’s Hospital Association website. Accessed March 16, 2018.
3. Goldman, JL, Richardson, T, Newland, JG, et al. Outpatient parenteral antimicrobial therapy in pediatric medicaid enrollees. J Pediatr Infect Dis Soc 2017;6:6571.
4. Zaoutis, T, Localio, AR, Leckerman, K, Saddlemire, S, Bertoch, D, Keren, R. Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children. Pediatrics 2009;123:636642.
5. Keren, R, Shah, SS, Srivastava, R, et al. Comparative effectiveness of intravenous vs oral antibiotics for postdischarge treatment of acute osteomyelitis in children. JAMA Pediatrics 2015;169:120128.
6. Shah, SS, Srivastava, R, Wu, S, et al. Intravenous versus oral antibiotics for postdischarge treatment of complicated pneumonia. Pediatrics 2016;138:9.
7. Broom, J, Broom, A, Adams, K, Plage, S. What prevents the intravenous to oral antibiotic switch? A qualitative study of hospital doctors’ accounts of what influences their clinical practice. J Antimicrob Chemother 2016;71:22952299.
8. Jones, M, Huttner, B, Madaras-Kelly, K, et al. Parenteral to oral conversion of fluoroquinolones: low-hanging fruit for antimicrobial stewardship programs? Infect Control Hosp Epidemiol 2012;33:362367.
9. McPherson, C, Lee, BR, Terrill, C, et al. Characteristics of pediatric antimicrobial stewardship programs: current status of the Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) collaborative. Antibiotics (Basel) 2018;7.
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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