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Respiratory Fluoroquinolone Use and Influenza

  • Philip M. Polgreen (a1), Ming Yang (a2), Ramanan Laxminarayan (a3) and Joseph E. Cavanaugh (a2)


We show that respiratory fluoroquinolone use is extremely seasonal and that fluoroquinolone use is strongly associated with influenza. In our time series model, instantaneous influenza activity was a significant predictor of use (P< .0001). Also, we estimated that reducing influenza activity by 20% would reduce prescriptions by 8%.


Corresponding author

Division of Infectious Diseases, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 (


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