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Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients

  • Jennie H. Kwon (a1), Kerry M. Bommarito (a1), Kimberly A. Reske (a1), Sondra M. Seiler (a1), Tiffany Hink (a1), Hilary M. Babcock (a1), Marin H. Kollef (a2), Victoria J. Fraser (a1), Carey-Ann D. Burnham (a3) and Erik R. Dubberke (a1)...


This was a randomized controlled pilot study of Lactobacillus rhamnosus GG versus standard of care to prevent gastrointestinal multidrug-resistant organism colonization in intensive care unit patients. Among 70 subjects, there were no significant differences in acquisition or loss of any multidrug-resistant organisms (P>.05) and no probiotic-associated adverse events.

Infect. Control Hosp. Epidemiol. 2015;36(12):1451–1454


Corresponding author

Address correspondence to Jennie H. Kwon, DO, Washington University School of Medicine, Division of Infectious Diseases, 6600 S Euclid Ave, Campus Box 8051, St. Louis, MO 63110 (


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1. Lambert, ML, Suetens, C, Savey, A, et al. Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study. Lancet Infect Dis 2011;11:3038.
2. Brusselaers, N, Vogelaers, D, Blot, S. The rising problem of antimicrobial resistance in the intensive care unit. Ann Intensive Care 2011;23:47.
3. Donskey, CJ. The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin Infect Dis 2004;39:219226.
4. Hink, T, Burnham, CA, Dubberke, ER. A systematic evaluation of methods to optimize culture-based recovery of Clostridium difficile from stool specimens. Anaerobe 2013;19:3943.
5. de Regt, MJ, Willems, RJ, Hene, RJ, et al. Effects of probiotics on acquisition and spread of multiresistant enterococci. Antimicrob Agents Chemother 2010;54:28012805.
6. Allen, SJ, Wareham, K, Wang, D, et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2013;382:12491257.
7. Goldenberg, JZ, Ma, SS, Saxton, JD, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst 2013;5:CD006095.
8. Plummer, S, Weaver, MA, Harris, JC, et al. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. Int Microbiol 2004;7:5962.
9. Barraud, E, Bollaert, PE, Gibot, S. Impact of the administration of probiotics on mortality in critically ill adult patients: a meta-analysis of randomized controlled trials. Chest 2013;143:646655.
10. Petrof, EO, Dhaliwal, R, Manzanares, W, et al. Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med 2012;40:32903302.


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