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Prospective Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low-Incidence Setting

  • Kristin J. Cummings (a1), Tamara S. Smith (a2), Elizabeth S. Shogren (a1), Rashida Khakoo (a3), Sharmilarani Nanda (a4), Lana Bunner (a5), Ann Smithmyer (a6), Darlene Soccorsi (a6), Michael L. Kashon (a7), Gerald H. Mazurek (a8), Lloyd N. Friedman (a9) and David N. Weissman (a1)...

Abstract

We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among 182 low-risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression.

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Corresponding author

National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS-2800, Morgantown, WV 26505 (cvx5@cdc.gov)

References

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Prospective Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low-Incidence Setting

  • Kristin J. Cummings (a1), Tamara S. Smith (a2), Elizabeth S. Shogren (a1), Rashida Khakoo (a3), Sharmilarani Nanda (a4), Lana Bunner (a5), Ann Smithmyer (a6), Darlene Soccorsi (a6), Michael L. Kashon (a7), Gerald H. Mazurek (a8), Lloyd N. Friedman (a9) and David N. Weissman (a1)...

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