1.Richards, MJ, Edwards, JR, Culver, DH, et al.Nosocomial infections in pediatric intensive care units in the United States: National Nosocomial Infections Surveillance System. Pediatrics 1999;103:e39.
2.Raad, I. Intravascular-catheter-related infections. Lancet 1998;351:893–898.
3.Singh-Naz, N, Sprague, BM, Patel, KM, Pollack, MM. Risk factors for nosocomial infection in critically ill children: a prospective cohort study. Crit Care Med 1996;24:875–878.
4.Stockwell, J. Nosocomial infections in the PICU: affecting the impact on safety and outcome. Pediatr Crit Care Med 2007;8:S21–S37.
5.National Nosocomial Infections Surveillance System. National Nosocomial Infections Surveillance System (NNIS) system report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004;32:470–485.
6.Slonim, AD, Kurtines, HC, Sprague, BM, Singh, N. The costs associated with nosocomial bloodstream infections in the pediatric intensive care unit. Pediatr Crit Care Med 2001;2:170–174.
7.Warren, DK, Zack, JE, Cox, MJ, Cohen, MM, Fraser, VJ. An educational intervention to prevent catheter-associated bloodstream infections in a nonteaching, community medical center. Crit Care Med 2003;31:1959–1963.
8.Higuera, F, Rosenthal, VD, Duarte, P, Ruiz, J, Franco, G, Safdar, N. The effect of process control on the incidence of central venous catheter-associated bloodstream infections and mortality in intensive care units in Mexico. Crit Care Med 2005;33:2022–2027.
9.Lobo, RD, Levin, AS, Brasileiro Gomes, LM, et al. Impact of an educational program and policy changes on decreasing catheter-associated bloodstream infections in a medical intensive care unit in Brazil. Am J Infect Control 2005;33:83–87.
10.Berenholtz, SM, Pronovost, PJ, Lipsett, PA, et al.Eliminating catheter-related bloodstream infections in the intensive care unit. Crif Care Med 2004;32:2014–2020.
11.Bhutta, A, Gilliam, C, Honeycutt, M, et al.Reduction of bloodstream infections associated with catheters in pediatric intensive care unit: stepwise approach. BMJ 2007;334:362–365.
12.Warren, DK, Cosgrove, SE, Diekema, DJ, et al.A multicenter intervention to prevent catheter-associated bloodstream infections. Infect Control Hosp Epidemiol 2006;27:662–669.
13.Pronovost, P, Needham, D, Berenholtz, S, et al.An intervention to decrease catheter-related bloodstream infections in the ICU (published correction appears in N Engl J Med 2007;356:2660). N Engl J Med 2006;355:2725–2732.
14.O'Grady, NP, Alexander, M, Dellinger, EP, et al.Guidelines for the prevention of intravascular catheter-related infections. Pediatrics 2002;110:e51.
15.Elward, AM, Hollenbeak, CS, Warren, DK, Fraser, VJ. Attributable cost of nosocomial primary bloodstream infection in pediatric intensive care unit patients. Pediatrics 2005;115:868–872.
16.Little, RA, Rubin, DB. Statistical Analysis With Missing Data. New York: Wiley; 1987.
17.Trautner, BW, Darouiche, RO. Catheter-associated infections: pathogenesis affects prevention. Arch Intern Med 2004;164:842–850.
18.Crnich, C, Maki, D. The promise of novel technology for the prevention of intravascular device-related bloodstream infection. I. Pathogenesis and short-term devices. Clin Infect Dis 2002;34:1232–1242.
19.Pittet, D, Hugonnet, S, Harbath, S, et al.Effectiveness of a hospital-wide programme to improve compliance with hand hygiene: Infection Control Programme. Lancet 2000;356:1307–1312.
20.Larson, EL. APIC guideline for hand washing and hand antisepsis in health care settings. Am J Infect Control 1995;23:251–269.
21.Raad, I, Hohn, D, Gilbreath, B, et al.Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol 1994;15:231–238.
22.Maki, DG, Ringer, M, Alvarado, CJ. Prospective randomized trial of pov-idone-iodine, alcohol, and Chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet 1991;338:339–343.
23.Chayiakunapruk, N, Veenstra, DL, Lipsky, BA, Saint, SJ. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792–801.
24.Lederle, FA, Parenti, CM, Berskow, LC, Ellingson, KJ. The idle intravenous catheter. Ann Intern Med 1992;116:737–738.
25.Costello, JM, Forbes Morrow, D, Graham, DA, Potter-Bynoe, G, Sandora, TJ, Laussen, PC. Systematic intervention to reduce central line-associated bloodstream infection rates in a pediatric cardiac intensive care unit. Pediatrics 2008;121:915–923.
26.Pronovost, PJ, Angus, DC, Dorman, T, et al.Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA 2002;288:2151–2162.