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Penicillin allergy and association with ciprofloxacin coverage in community-onset urinary tract infection

  • Courtney M. Dewart (a1), Yuan Gao (a2), Protiva Rahman (a3), Awa Mbodj (a4), Erinn M. Hade (a4), Kurt Stevenson (a1) (a5) and Courtney L. Hebert (a4) (a5)...


Corresponding author

Author for correspondence: Courtney L. Hebert, Department of Biomedical Informatics, The Ohio State University College of Medicine, 220S Lincoln Tower, 1800 Cannon Drive, Columbus, OH 43210. E-mail:


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1. Shah, NS, Ridgway, JP, Pettit, N, Fahrenbach, J, Robicsek, A. Documenting penicillin allergy: the impact of inconsistency. PLoS One 2016;11:e0150514.
2. Macy, E, Contreras, R. Health care use and serious infection prevalence associated with penicillin “allergy” in hospitalized patients: a cohort study. J Allergy Clin Immunol 2014;133:790796.
3. Sogn, DD, Evans, R, Shepherd, GM, et al. Results of the National Institute of Allergy and Infectious Diseases Collaborative Clinical Trial to test the predictive value of skin testing with major and minor penicillin derivatives in hospitalized adults. Arch Intern Med 1992;152:10251032.
4. Trubiano, JA, Chen, C, Cheng, AC, Grayson, ML, Slavin, MA, Thursky, KA. Antimicrobial allergy “labels” drive inappropriate antimicrobial prescribing: lessons for stewardship. J Antimicrob Chemother 2016;71:17151722.
5. Killgore, KM, March, KL, Guglielmo, BJ. Risk factors for community-acquired ciprofloxacin-resistant Escherichia coli urinary tract infection. Ann Pharmacother 2004;38:11481152.
6. Hebert, C, Ridgway, J, Vekhter, B, Brown, EC, Weber, SG, Robicsek, A. Demonstration of the weighted-incidence syndromic combination antibiogram: an empiric prescribing decision aid. Infect Control Hosp Epidemiol 2012;33:381388.
7. Zou, G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004;159:702706.
8. Austin, PC, Stuart, EA. Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Statist Med 2015;4:36613679.
9. Tingley, D, Yamamoto, T, Hirose, K, Imai, K, Keele, L. Mediation: R package for causal mediation analysis. J Statist Soft 2014;59:138.
10. Bourke, J, Pavlos, R, James, I, Phillips, E. Improving the effectiveness of penicillin allergy de-labeling. J Allerg Clin Immunol Pract 2015;3:365374.


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