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Oxacillin- and Quinolone-Resistant Staphylococcus Aureus in Sao Paulo, Brazil: A Multicenter Molecular Epidemiology Study

Published online by Cambridge University Press:  21 June 2016

Helio S. Sader ,
Antonio C. Pignatari ,
Richard J. Hollis ,
Ivani Leme  and
Ronald N. Jones
Helio S. Sader*
Affiliation:
Disciplina de Doencas Infecciosas e Parasitarias, Escola Paulista de Medicina, Sao Paulo, Brazil Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Antonio C. Pignatari
Affiliation:
Disciplina de Doencas Infecciosas e Parasitarias, Escola Paulista de Medicina, Sao Paulo, Brazil Hospital IX de Julho, Sao Paulo, Brazil
Richard J. Hollis
Affiliation:
Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
Ivani Leme
Affiliation:
Disciplina de Doencas Infecciosas e Parasitarias, Escola Paulista de Medicina, Sao Paulo, Brazil
Ronald N. Jones
Affiliation:
Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa
*
University of Iowa College of Medicine, Department of Pathology, 273 MRC, Iowa City, IA 52242
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Abstract

Objective:

To investigate the possibility of interhospital spread of multiresistant Staphylococcus aureus in Sao Paulo, Brazil.

Design:

We evaluated 13 nosocomial S aureus strains selected because of resistance to oxacillin and ciprofloxacin.

Setting:

The strains were collected between March 1991 and September 1991 from four hospitals in Sao Paulo. Two were teaching hospitals, and two were private hospitals.

Patients:

Each strain was isolated from a different patient. All patients were hospitalized when the strains were isolated.

Interventions:

The strains were typed by restriction endonuclease analyses of plasmid DNA (REAP) using EcoRI, HindIII, RsaI, and Alu1 and by extended antibiogram profile (34 drugs).

Results:

All strains had identical plasmid and antibiogram profile. They demonstrated the same plasmid pattern as previously described in one of the hospitals studied.

Conclusions:

Our results suggest the dissemination of a unique oxacillin- and quinolone-resistant strain of S aureus in several hospitals of Sao Paulo, Brazil.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 14 , Issue 5 , May 1993 , pp. 260 - 264
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1993

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