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Nosocomial Mycobacterial Pseudoinfection in a Georgia Hospital

  • Richard A. Goodman (a1), J. David Smith (a1), George P. Kubica (a1), Ellen M. Dougherty (a1) and R. Keith Sikes (a1)...

Abstract

Nosocomial pseudoepidemics may be detected when clustering of pseudoinfections occur or when artificial clusters of real infection are observed. Nontuberculous mycobacteria were reportedly isolated from specimens obtained from seven patients at one hospital from October 1980 to January 1981. Because the patients' clinical illnesses were not uniformly consistent with mycobacterial disease, we hypothesized that pseudoinfections had occurred and searched for a common source of contamination. The investigation suggested that specimen contamination was associated with one microbiology laboratory technician: 6 of 22 (27%) specimens processed by that person were positive compared with 1 of 103 (1%) specimens processed by the other five technicians. However, a specific mechanism of contamination was not identified. Nosocomial pseudoepidemics associated with false infections should be suspected and investigated when clinical features and laboratory findings do not agree.

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Corresponding author

Division of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90024

References

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1.Norden, CW: Pseudosepticemia. Ann Intern Med 1969;71:789790.
2.Weinstein, RA, Stamm, WE: Pseudoepidemics in hospital. Lancet 1977; 2(8043):862864.
3.Maki, DG: Through a glass darkly: Nosocomial pseudoepidemics and pseudobacteremias. Arch Intern Med 1980;140:2628.
4.Kusek, JW: Nosocomial pseudoepidemics and pseudoinfections: An increasing problem. Am J Infect Control 1981;9:7075.
5.King, LS: Let this be a lesson to you! JAMA 1972;219:81.
6.Berkelman, RL, Lewin, S, Allen, JR, et al: Pseudobacteremia attributed to contamination of povidone-iodine with Pseudomonas cepacia. Ann Intern Med 1981;95:3236.
7.Noble, RC, Reeves, SA: Bacillus species Pseudosepsis caused by contaminated commercial blood culture media. JAMA 1974;230:10021004.
8.Hoffman, PC, Arnow, PM, Goldmann, DA, et al: False-positive blood cultures: Association with nonsterile blood collection tubes. JAMA 1976;236:20732075.
9.Griffin, MR, Miller, AD, Davis, AC: Blood culture cross contamination associated with a radiometric analyzer. J Clin Microbiol 1982;15:567570.
10.Greenhood, GP, Highsmith, AK, Allen, JR, et al: Klebsiella pneumoniae pseudobacteremia due to cross-contamination of a radiometric blood culture analyzer. Infect Control 1981;2:460465.
11.Faris, HM Jr, Sparling, PF: Mima polymorpha bacteremia: False-positive cultures due to contaminated penicillinase. JAMA 1972;219:7677.
12.Lynch, JM, Anderson, A, Camacho, FR, et al: Pseudobacteremia caused by Clostridium sordellei. Arch Intern Med 1980;140:6568.
13.Berger, SA: Pseudobacteremia due to contaminated alcohol swabs. J Clin Microbiol 1983;18:974975.
14.Macdonald, N: Investigation of an outbreak pseudobacteremia attributed to bacillus species in a general hospital, abstracted. 82nd Annual Meeting of the American Society for Microbiology, Atlanta, Georgia, March 7-12, 1982, p 83.
15.Laxson, L, Schultz, A, Kane, M: Pseudo-outbreak of hepatitis B in a transplant unit may answer transient positive question, abstracted. 8th Annual Conference of the Association for Practitioners in Infection Control, Atlanta, Georgia, May 17-21, 1981, p 24.
16.Nunez, D, Stanley, C, Robertstad, GW, et al: Pseudoepidemic of coccidioidomycosis. Am J Infect Control 1982;10:6871.
17.Centers for Disease Control. Pseudobacteremia due to Staphylococcus aureus—New York. MMWR 1979;28:8283.
18.Spivak, ML, Shannon, R, Natsios, GA, et al: Two epidemics of pseudobacteremia due to Staphylococcal aureus and Aerococcus vir-idans. Infect Control 1980;1:321323.
19.Graham, DR, Wu, E, Highsmith, AK, et al: An outbreak of pseudobacteremia caused by Enterobacter cloacae from a phlebotomist's vial of thrombin. Ann Intern Med 1981;95:585588.

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