Hostname: page-component-7bb8b95d7b-cx56b Total loading time: 0 Render date: 2024-09-18T09:57:30.905Z Has data issue: false hasContentIssue false
  • English
  • Français

A New Synergized Glutaraldehyde-Phenate Sterilizing Solution and Concentrated Disinfectant

Published online by Cambridge University Press:  02 January 2015

Eddie D. Leach
Eddie D. Leach*
Affiliation:
Milligan College, Milligan College, Tennessee
*
Milligan College, Milligan College, TN 37682
Get access Rights & Permissions [Opens in a new window]

Abstract

Research leading to the development of Sporicidin, a new (synergized glutaraldehyde-phenate) sterilant and concentrated disinfectant, is reported. Microbial evaluation and shelf life testing of the new formulation was done using AOAC tests—Use-Dilution, Sporicidal, Tuberculocidal—and the E.P.A. Virucidal Test. Full-strength Sporicidin sterilizes (is sporicidal) in 6% hours at both 20C and 25C, and disinfects in 1-2 minutes. When diluted with 15 parts of tap water, Sporicidin is tuberculocidal, virucidal, and germicidal in 10 minutes, qualifying as a hospital disinfectant that will not “yellow” the hands or skin. The shelf life of activated Sporidicin, full strength or diluted 1 in 16, is 30 days. According to the data presented, which were the basis of E.P.A. registrations, Sporicidin is: (a) the fastest glutaraldehyde sterilant at room temperature, and (b) the only glutaraldehyde product that can be diluted below 2% and still qualify as a hospital disinfectant.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 2 , Issue 1 , February 1981 , pp. 26 - 30
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Block, SS. Disinfection, Sterilization and Preservation. (Ed 2). Philadelphia, Lea & Febiger, 1977.CrossRefGoogle Scholar
2.Borick, PM, Pepper, RE. The spore problem. In: Benarde, MA (ed). Disinfection. New York, Marcel Dekker, 1970.Google Scholar
3.Spaulding, EH. Chemical disinfection in the hospital. J Hosp Res 1964;9:5–25.Google Scholar
4.Borick, PM (ed). Chemical Disinfection. Stroudsburg, PA, Dowden, Hutchinson & Ross, 1973.Google Scholar
5.Adair, FW, Geftic, SG, Gelzer, J. Resistance of Pseudomonas to quaternary ammonium compounds. I. Growth in benzalkonium chloride solution. Appl Microbiol 1969;18:299–302.CrossRefGoogle ScholarPubMed
6.Lee, JC, Fialkow, PJ. Benzalkonium chloride—source of hospital infection with gram-negative bacteria. JAMA 1961;177(10):708–710.CrossRefGoogle ScholarPubMed
7.Hirsch, JG. The resistance of tubercle bacilli to the bactericidal action of benzalkonium chloride (Zepharin). Am Rev Tuberc 1954;70:312–319.Google Scholar
8.Mehta, P. Disinfection of medical and surgical materials. Am J Hosp Pharm 1971;28:454–456.Google ScholarPubMed
9.Borick, PM. Chemical sterilizers (Chemosterilizers). In: Advances in Applied Microbiology 1968;10:302.Google Scholar
10.Editorial. Formaldehyde toxicity. Lancet 1979;2(8143):620–621.Google Scholar
11.Pepper, RE, Chandler, VL. Sporicidal activity of alkaline alcoholic saturated dialdehyde solutions. Appl Microbiol 1963;11:384–388.CrossRefGoogle ScholarPubMed
12.Stonehill, AA, Krop, S, Borick, PM. Buffered glutaraldehyde, a new chemical sterilizing solution. Am J Hosp Pharm 1963;20:458–465.Google Scholar
13.Borick, PM, Dondershine, FH, Chandler, VL. Alkalinized glutaraldehyde, a new antimicrobial agent. J Pharm Sci 1964;53:1273–1275.CrossRefGoogle ScholarPubMed
14.Snyder, RW, Cheatle, EL. Alkaline glutaraldehyde, an effective disinfectant. Am J Hosp Pharm 1965;22:321–327.Google Scholar
15.Pepper, RE, Lieberman, ER. Dialdehyde alcoholic sporicidal composition. U.S. Patent No. 3,016,328, 1962.Google Scholar
16.Rasmussen, KE, Albrechtsen, J. Glutaraldehyde. The influence of pH, temperature, and buffering on the polymerization rate. Histochem 1974;38:19–26.CrossRefGoogle Scholar
17.Miner, NA, McDowell, JW, Willcockson, GWet al.Antimicrobial and other properties of a new stabilized alkaline glutaraldehyde disinfectant/sterilizer. Am J Hosp Pharm 1977;34:376–382.Google ScholarPubMed
18.Boucher, RMG. Advances in sterilization techniques, state of the art and recent breakthroughs. Am J Hosp Pharm 1972;29:661–672.Google ScholarPubMed
19.Boucher, RMG. Potentiated acid 1,5 pentanedial solution—a new chemical sterilizing and disinfecting agent. Am J Hosp Pharm 1974;31:546–557.Google Scholar
20.Pepper, RE. Comparison of the activities and stabilities of alkaline glutaraldehyde sterilizing solutions. Infect Control 1980;1:90–92.CrossRefGoogle ScholarPubMed
21.Schattner, RI. Buffered phenol-glutaraldehyde sterilizing compositions. U.S. Patent No. 4,103,001, 1978.Google Scholar
22.Horowitz, W. Official Methods of Analysis of the Association of Official Analytical Chemists. (12th ed). Washington, D.C., Association of Official Analytical Chemists, 1975.Google Scholar
23. Federal Register 10, No. 123, 25 June 1975, p. 26836.Google Scholar
24.Prince, H. Antiviral studies with aged Sporicidin. Report No. 10602, Reference 35-146-55, Gibraltar Biological Laboratories, Inc., Fairfield, NJ. Sept 14, 1979.Google Scholar
25.Meltzer, N, Henkin, H. Glutaraldehyde: A new preservative for cosmetics. Sixth Congress of International Federation of Societies of Cosmetic Chemists 1970;11:833–850.Google Scholar
26.Lyon, TC. Allergic contact dermatitis due to Cidex, report of a case. Oral Surg, Oral Med, Oral Path 1971;32:895–898.CrossRefGoogle ScholarPubMed
27.Council on Dental Therapeutics. Council announces classification of additional products. 1978; JADA 97:857–859.Google Scholar
28.Council on Dental Therapeutics. Council accepts dilution claims for Sporicidin. 1980; JADA 100:918.Google Scholar