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Lack of false-positive results for Clostridioides difficile toxins A and B using two commercial enzyme immunoassays in pediatric patients

  • Aakash B. Balaji (a1), Joseph S. Sichel (a1) and Larry K. Kociolek (a1) (a2)

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*Author for correspondence: Larry K. Kociolek, Email: larry-kociolek@northwestern.edu

References

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1. Burnham, CA, Dubberke, ER, Kociolek, LK, Polage, CR, Riley, TV. Clostridium difficile-diagnostic and clinical challenges. Clin Chem 2016;62:310314.
2. Burnham, CA, Carroll, KC. Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories. Clin Microbiol Rev 2013;26:604630.
3. Polage, CR, Gyorke, CE, Kennedy, MA, et al. Overdiagnosis of Clostridium difficile infection in the molecular test era. JAMA Intern Med 2015;175: 17921801.
4. Planche, TD, Davies, KA, Coen, PG, et al. Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection. Lancet Infect Dis 2013;13:936945.
5. McDonald, LC, Gerding, DN, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018;66(7):e1e48.
6. Toltzis, P, Nerandzic, MM, Saade, E, et al. High proportion of false-positive Clostridium difficile enzyme immunoassays for toxin A and B in pediatric patients. Infect Control Hosp Epidemiol 2012;33:175179.
7. Sandora, TJ, Bryant, KK, Cantey, JB, Elward, AM, Yokoe, DS, Bartlett, AH. SHEA neonatal intensive care unit (NICU) white paper series: practical approaches to Clostridioides difficile prevention. Infect Control Hosp Epidemiol 2018;39:11491153.
8. Kociolek, LK, Patel, SJ, Shulman, ST, Gerding, D. Molecular epidemiology of Clostridium difficile infections in children: a retrospective cohort study. Infect Control Hosp Epidemiol 2015;36:445451.
9. Kociolek, LK, Sandora, TJ. National variability in surveillance, testing, and infection prevention for Clostridium difficile infection in pediatric populations. Am J Infect Control 2013;41:933935.
10. Kociolek, LK, Kutty, P, Polgreen, PM, Beekman, SE. Healthcare provider diagnostic testing practices for identification of Clostridioides (Clostridium) difficile in children: an Emerging Infections Network survey. Infect Control Hosp Epidemiol 2019;40:276280.

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