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Intradermal Recombinant Hepatitis B Vaccine for Healthcare Workers Who Fail to Respond to Intramuscular Vaccine

  • E. Geoffrey Playford (a1), Patrick G. Hogan (a2), Amolak S. Bansal (a2), Kareena Harrison (a1), David Drummond (a3), David F. M. Looke (a1) and Michael Whitby (a1)...

Abstract

Objective:

To study the humoral immune responses, safety, and tolerability of intradermal recombinant hepatitis B vaccination in healthcare workers (HCWs) nonresponsive to previous repeated intramuscular vaccination.

Design:

An open, prospective, before–after trial.

Setting:

A tertiary referral hospital and surrounding district health service in Queensland, Australia.

Participants:

Hospital and community HCWs nonresponsive to previous intramuscular hepatitis B vaccination.

Methods:

Intradermal recombinant hepatitis B vaccine was administered every second week for a maximum of 4 doses. Hepatitis B surface antibody (anti-HBs) responses were assessed 2 weeks after each dose.

Results:

Protective anti-HBs levels developed in 17 (94%) of 18 study subjects. Three doses resulted in seroconversion of all responding subjects and the highest geometric mean antibody concentration. The vaccine was well tolerated.

Conclusion:

More than 90% of previously nonresponsive HCWs responded to intradermal recombinant hepatitis B vaccine with protective anti-HBs levels.

Copyright

Corresponding author

Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia

References

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Intradermal Recombinant Hepatitis B Vaccine for Healthcare Workers Who Fail to Respond to Intramuscular Vaccine

  • E. Geoffrey Playford (a1), Patrick G. Hogan (a2), Amolak S. Bansal (a2), Kareena Harrison (a1), David Drummond (a3), David F. M. Looke (a1) and Michael Whitby (a1)...

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