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The impact of formulary restriction on the relative consumption of carbapenems in intensive care units at an academic medical center

  • Jacob W. Pierce (a1), Andrew Kirk (a2), Kimberly B. Lee (a3), John D. Markley (a4), Amy Pakyz (a5), Gonzalo Bearman (a3) (a6), Michelle E. Doll (a3) (a6) and Michael P. Stevens (a3) (a6)...


Antipseudomonal carbapenems are an important target for antimicrobial stewardship programs. We evaluated the impact of formulary restriction and preauthorization on relative carbapenem use for medical and surgical intensive care units at a large, urban academic medical center using interrupted time-series analysis.


Corresponding author

Author for correspondence: Michael P. Stevens, E-mail:


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1. CDC. Antibiotic resistance threats in the United States, 2013. Current 2013;00. doi: CS239559-B.
2. Livorsi, DJ, Chorazy, ML, Schweizer, ML, et al. A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States. Antimicrob Resist Infect Control 2018;7:19.
3. Baggs, J, Fridkin, SK, Pollack, LA, Srinivasan, A, Jernigan, JA. Estimating national trends in inpatient antibiotic use among US hospitals from 2006 to 2012. JAMA Intern Med 2016;176:16391648.
4. Klein, EY, Van Boeckel, TP, Martinez, EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci 2018. doi: 10.1073/pnas.1717295115.
5. Hirayama, S, Yasui, K, Murakami, H, et al. A new carbapenem drug dosage metric for carbapenem usage and correlation with carbapenem resistance of Pseudomonas aeruginosa. J Infect Chemother 2018;24:949953.
6. Ogutlu, A, Guclu, E, Karabay, O, Utku, AC, Tuna, N, Yahyaoglu, M. Effects of carbapenem consumption on the prevalence of acinetobacter infection in intensive care unit patients. Ann Clin Microbiol Antimicrob 2014;13:16.
7. Remschmidt, C, Schneider, S, Meyer, E, Schroeren-Boersch, B, Gastmeier, P, Schwab, F. Surveillance of antibiotic use and resistance in intensive care units (SARI)—a 15-year cohort study. Dtsch Arztebl Int 2017;114:858865.
8. Luyt, C-E, Bréchot, N, Trouillet, J-L, Chastre, J. Antibiotic stewardship in the intensive care unit. Crit Care 2014;18:480.
9. Dellit, TH, Owens, RC, Mcgowan, JE, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. 2007;44:159177.
10. Markley, JD, Pakyz, AL, Sabo, RT, Bearman, G, Hohmann, SF, Stevens, MP. Performance of a novel antipseudomonal antibiotic consumption metric among academic medical centers in the United States. 2015;39(2).


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