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High frequency of Clostridium difficile infections in Brazil: Results from a multicenter point-prevalence study

  • Renata N. Pires (a1) (a2), Diego R. Falci (a3) (a4), Alexandre A. Monteiro (a1), Cassia F.B. Caurio (a1) (a2), Felipe F. Tuon (a5), Eduardo A. Medeiros (a6), Ivan L. França (a7), Josiane F. John (a8), Teresa C.T. Sukiennik (a2), Gabriele Z. Saldanha (a9), Andreza F. Martins (a9) and Alessandro C. Pasqualotto (a1) (a2)...


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Author for correspondence: Alessandro C. Pasqualotto, Email:


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1.Pires, RN, Monteiro, AA, Carneiro, LC, et al. Clostridium difficile infection in Brazil: a neglected problem? Am J Infect Control 2014;42:459460.
2.McDonald, LC, Gerding, DN, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clostridium difficile 2018;66:987994.
3.Balassiano, IT, Yates, EA, Domingues, RM, Ferreira, EO. Clostridium difficile: a problem of concern in developed countries and still a mystery in Latin America. J Med Microbiol 2012;61:169179.
4.Kok, J, Wang, Q, Thomas, LC, Gilbert, GL. Presumptive identification of Clostridium difficile strain 027/NAP1/BI on Cepheid Xpert: interpret with caution. J Clin Microbiol 2011;49:37193721.
5.Lopes Cançado, GG, Silveira Silva, RO, Rupnik, M, et al. Clinical epidemiology of Clostridium difficile infection among hospitalized patients with antibiotic-associated diarrhea in a university hospital of Brazil. Anaerobe 2018;54:6571.10.1016/j.anaerobe.2018.08.005
6.Costa, CL, Carvalho, CBM, González, RH, et al. Molecular epidemiology of Clostridium difficile infection in a Brazilian cancer hospital. Anaerobe 2017;48:232236.
7.Monot, M, Eckert, C, Lemire, A, et al. Clostridium difficile: new insights into the evolution of the pathogenicity locus. Sci Rep 2015;5:15023.
8.Merrigan, MM, Venugopal, A, Roxas, JL, et al. Surface-layer protein A (SlpA) is a major contributor to host-cell adherence of Clostridium difficile. PLoS One 2013;8:e78404.10.1371/journal.pone.0078404


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