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Epidemiology of Sepsis in the Valencian Community (Spain), 1995–2004

Published online by Cambridge University Press:  02 January 2015

Juan Carlos Andreu Ballester ,
Ferran Ballester ,
Antonio González Sánchez ,
Amadeo Almela Quilis ,
Enrique Colomer Rubio  and
Carlos Peñarroja Otero
Juan Carlos Andreu Ballester*
Affiliation:
Departments of Emergency Medicine, Arnau de Vilanova Hospital, Valencia, Spain
Ferran Ballester
Affiliation:
Unit of Epidemiology and Statistics, Valencian School of Studies for Health, Valencia, Spain
Antonio González Sánchez
Affiliation:
Documentation and Admission, Arnau de Vilanova Hospital, Valencia, Spain
Amadeo Almela Quilis
Affiliation:
Departments of Emergency Medicine, Arnau de Vilanova Hospital, Valencia, Spain
Enrique Colomer Rubio
Affiliation:
Departments of Emergency Medicine, Arnau de Vilanova Hospital, Valencia, Spain
Carlos Peñarroja Otero
Affiliation:
Internal Medicine Department, Casa de Salud Hospital, Valencia, Spain
*
San Clemente 12, Valencia 46015, Spain (jcandreu@ono.com)
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Abstract

Objective.

To study the incidence of sepsis in the Valencian Community (Spain) during a period of 10 years (1995–2004).

Methods.

We downloaded data on discharge diagnoses of septicemia in all 26 public hospitals in the Valencian Community during the 10-year study period, as well as the additional discharge diagnoses of each patient.

Results.

We identified 33,767 cases of sepsis during the study period. The age-standardized incidence rates among men increased from 64.11 (95% confidence interval [CI], 60.37–67.85) cases per 100,000 population in 1995 to 114.02 (95% CI, 109.02–118.50) cases per 100,000 population in 2004 (P < .001), and those among women increased from 45.08 (95% CI, 42.01–48.15) cases per 100,000 population in 1995 to 83.62 (95% CI, 79.85–87.39) cases per 100,000 population in 2004 (P < .001). Gram-negative bacteria were the most frequently involved microorganisms (in 21.4% of cases), and there was a significant increase in the number of sepsis cases caused by these organisms from 1999 onward. The mortality rate was approximately 42.5% among patients hospitalized for sepsis, and mortality was associated with organ failure. In addition, mortality was associated with the microorganism responsible not being known, with infection due to fungi, and with polymicrobial sepsis.

Conclusions.

The rates of hospitalization both for sepsis overall and for severe sepsis in the Valencian Community (Spain) are lower than those in other countries but are increasing, by 5% each year. The increase in the number of cases in which gram-negative bacteria are the cause of sepsis is notable.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 29 , Issue 7 , July 2008 , pp. 630 - 634
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

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