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Epidemiology of Antimicrobial Resistance among Gram-Negative Organisms Recovered from Patients in a Multistate Network of Long-Term Care Facilities

  • Ebbing Lautenbach (a1) (a2) (a3) (a4), Roseann Marsicano (a5), Pam Tolomeo (a3), Michael Heard (a5), Steve Serrano (a5) and Donald D. Stieritz (a5)...

Abstract

We identified 1,805 gram-negative organisms in cultures of urine samples obtained over a 10-month period from residents of 63 long-term care facilities. The prevalence of fluoroquinolone resistance in Escherichia coli was 51% (446 of 874 isolates), whereas the preva¬lences of ceftazidime and imipenem resistance in Klebsiella species were 26% and 6% (84 and 19 of 323 isolates), respectively. The prevalence of resistance varied significantly by facility type, size, and geographic location.

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Corresponding author

University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021 (ebbing@mail.med.upenn.edu)

References

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1.Smith, PW, Bennett, G, Bradley, S, et al.SHEA/APIC guideline: infection prevention and control in the long-term care facility. Infect Control Hosp Epidemiol 2008;29:785814.
2.Viray, M, Linkin, D, Maslow, JN, et al.Longitudinal trends in antimicrobial susceptibilities across long term care facilities: emergence of fluoroquinolone resistance. Infect Control Hosp Epidemiol 2005;26:5662.
3.Strausbaugh, LJ, Crossley, KB, Nurse, BA, Thrupp, LD. Antimicrobial resistance in long-term care facilities. Infect Control Hosp Epidemiol 1996;17:129140.
4.Smith, PW, Rusnak, PG. Infection prevention and control in the long-term-care facility: SHEA Long-Term-Care Committee and APIC Guidelines Committee. Infect Control Hosp Epidemiol 1997;18:831849.
5.Yoshikawa, TT. Antimicrobial resistance and aging: beginning of the end of the antibiotic era? J Am Geriatr Soc 2002;50(suppl):S226229.
6.Nicolle, LE, Strausbaugh, LJ, Garibaldi, RA. Infections and antibiotic resistance in nursing homes. Clin Microbiol Rev 1996;9:117.
7. Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing: 18th informational supplement. Wayne, PA: CLSI, 2008:M100-S18.
8.Kleinbaum, DG, Kupper, LL, Morgenstern, H. Epidemiologie research:principles and quantitative methods. New York: Van Nostrand Reinhold; 1982.
9.Lipworth, AD, Hyle, EP, Fishman, NO, et al.Limiting the emergence of extended-spectrum β-lactamase-producing Enterobacteriaceae: influence of patient population characteristics on the response to antimicrobial formulary interventions. Infect Control Hosp Epidemiol 2006;27:27986.
10.Urban, C, Bradford, PA, Tuckman, M, et al.Carbapenem-resistant Escherichia coli harboring Klebsiella pneumoniae carbapenemase β-lactamases associated with long-term care facilities. Clin Infect Dis 2008;46:e127130.

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