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Efficacy of Combination of N-acetylcysteine, Gentamicin, and Amphotericin B for Prevention of Microbial Colonization of Ventricular Assist Devices

  • Maria D. Hernandez (a1), Mohammad D. Mansouri (a1) (a2), Saima Aslam (a3) (a4) (a1), Barry Zeluff (a4) and Rabih O. Darouiche (a3) (a1) (a2)...

Abstract

We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.

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Corresponding author

Center for Prostheses Infection, 1333 Moursund Avenue, Suite A221, Houston, TX 77030 (rdarouiche@aol.com)

References

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