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Effective Antibiotic Conservation by Emergency Antimicrobial Stewardship During a Drug Shortage

Published online by Cambridge University Press:  05 December 2016

Kevin Hsueh ,
Maria Reyes ,
Tamara Krekel ,
Ed Casabar ,
David J. Ritchie ,
S. Reza Jafarzadeh ,
Amanda J. Hays ,
Michael A. Lane  and
Michael J. Durkin
Kevin Hsueh*
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Maria Reyes
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Tamara Krekel
Affiliation:
Barnes-Jewish Hospital, St. Louis, Missouri
Ed Casabar
Affiliation:
Barnes-Jewish Hospital, St. Louis, Missouri
David J. Ritchie
Affiliation:
Barnes-Jewish Hospital, St. Louis, Missouri St. Louis College of Pharmacy, St. Louis, Missouri
S. Reza Jafarzadeh
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri
Amanda J. Hays
Affiliation:
Center for Clinical Excellence, BJC Healthcare, St. Louis, Missouri
Michael A. Lane
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri Center for Clinical Excellence, BJC Healthcare, St. Louis, Missouri
Michael J. Durkin
Affiliation:
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri Institute for Public Health, Washington University, St. Louis, Missouri.
*
Address correspondence to Kevin Hsueh, MD, Division of Infectious Diseases, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8051, St. Louis, MO, 63110 (khsueh@wustl.edu).
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Abstract

We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam by 73%. During the shortage period, hospital mortality decreased (P=.03), while hospital length of stay remained unchanged.

Infect Control Hosp Epidemiol 2017;38:356–359

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 38 , Issue 3 , March 2017 , pp. 356 - 359
Copyright
© 2016 by The Society for Healthcare Epidemiology of America. All rights reserved 

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References

REFERENCES

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