Skip to main content Accessibility help
×
×
Home

Effect of Intranasal Mupirocin Prophylaxis on Methicillin-Resistant Staphylococcus aureus Transmission and Invasive Staphylococcal Infections in a Neonatal Intensive Care Unit

  • Elizabeth H. Ristagno (a1), Kristina A. Bryant (a2), Lynette F. Boland (a3), Gordon G. Stout (a2), Alan D. Junkins (a4), Charles R. Woods (a2), John A. Myers (a2) and Claudia M. Espinosa (a2)...

Abstract

The use of monthly intranasal mupirocin was associated with a significant reduction in the rate of methicillin-resistant Staphylococcus aureus transmission and Staphylococcus aureus invasive infection in a large neonatal intensive care unit. Resistance to mupirocin emerged over time, but it was rare and was not associated with adverse clinical outcomes.

Infect Control Hosp Epidemiol 2018;39:741–745

Copyright

Corresponding author

Address correspondence to Claudia M. Espinosa, MD, Department of Pediatrics, University of Louisville, 571 S Floyd St Suite 321, Louisville, Kentucky (cmespi01@louisville.edu).

Footnotes

Hide All

PREVIOUS PRESENTATION. Findings presented at the Infectious Diseases Society of America’s IDWeek on October 10, 2015, in San Diego, California, and at the Society for Healthcare Epidemiology of America (SHEA) meeting on May 20, 2016, in Atlanta, Georgia.

Footnotes

References

Hide All
1. Huang, YC. Methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in neonatal intensive care units. Pediatrics 2006;118:469474.
2. Lally, RT, Lanz, E, Schrock, C. G. Rapid control of an outbreak of Staphylococcus aureus on a neonatal intensive care department using standard infection control practices and nasal mupirocin. Am J Infect Control 2004;32:4447.
3. Delaney, HM, Wang, E, Melish, M. Comprehensive strategy including prophylactic mupirocin to reduce Staphylococcus aureus colonization and infection in high-risk neonates. J Perinatol 2013;33:313318.
4. Song, X, Cheung, S, Klontz, K, Short, B, Campos, J, Singh, N. A stepwise approach to control an outbreak and ongoing transmission of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Am J Infect Control 2010;38:607611.
5. Antonov, NK, Garzon, MC, Morel, KD, Whittier, S, Planet, PJ, Lauren, CT. High prevalence of mupirocin resistance in Staphylococcus aureus isolates from a pediatric population. Antimicrob Agents Chemother 2015;59:33503356.
6. The Mupirocin Study Group. Nasal mupirocin prevents Staphylococcus aureus exit-site infection during peritoneal dialysis. J Am Soc Nephrol 1996;7:24032408.
7. Cochrane Effective Practice and Organisation of Care Review Group (EPOC). Data collection checklist—Cochrane Effective Practice and Organisation of Care Review Group. EPOC website. http://epoc.cochrane.org/sites/epoc.cochrane.org/files/uploads/datacollectionchecklist.pdf. Updated 2002. Accessed August 11, 2016.
8. Suwantarat, N, Carroll, KC, Tekle, T, Ross, T, Popoola, VO, Milstone, AM. Low prevalence of mupirocin resistance among hospital-acquired methicillin-resistant Staphylococcus aureus isolates in a neonatal intensive care unit with an active surveillance cultures and decolonization program. Infect Control Hosp Epidemiol 2015;36:232233.
9. Park, S, Kim, SY, Lee, JH, Park, C, Lee, DG. Community-genotype strains of methicillin-resistant Staphylococcus aureus with high-level mupirocin resistance in a neonatal intensive care unit. Early Hum Dev 2013;89:661665.
10. Pierce, R, Bryant, K, Lessler, J, Milstone, AM. Bacterial and fungal infections in neonates following mupirocin-based MRSA decolonization: a multicenter cohort study. Infect Control Hosp Epidemiol 2017;38:930936.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed