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Effect of Intranasal Mupirocin Prophylaxis on Methicillin-Resistant Staphylococcus aureus Transmission and Invasive Staphylococcal Infections in a Neonatal Intensive Care Unit

  • Elizabeth H. Ristagno (a1), Kristina A. Bryant (a2), Lynette F. Boland (a3), Gordon G. Stout (a2), Alan D. Junkins (a4), Charles R. Woods (a2), John A. Myers (a2) and Claudia M. Espinosa (a2)...


The use of monthly intranasal mupirocin was associated with a significant reduction in the rate of methicillin-resistant Staphylococcus aureus transmission and Staphylococcus aureus invasive infection in a large neonatal intensive care unit. Resistance to mupirocin emerged over time, but it was rare and was not associated with adverse clinical outcomes.

Infect Control Hosp Epidemiol 2018;39:741–745


Corresponding author

Address correspondence to Claudia M. Espinosa, MD, Department of Pediatrics, University of Louisville, 571 S Floyd St Suite 321, Louisville, Kentucky (


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PREVIOUS PRESENTATION. Findings presented at the Infectious Diseases Society of America’s IDWeek on October 10, 2015, in San Diego, California, and at the Society for Healthcare Epidemiology of America (SHEA) meeting on May 20, 2016, in Atlanta, Georgia.



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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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