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Does the Implementation of an Interferon-γ Release Assay in Lieu of a Tuberculin Skin Test Increase Acceptance of Preventive Therapy for Latent Tuberculosis Among Healthcare Workers?

  • Rajiv Sahni (a1), Cyndee Miranda (a1), Belinda Yen-Lieberman (a2) (a3), J. Walton Tomford (a1), Paul Terpeluk (a4), Pearl Quartey (a3), Lucileia T. Johnson (a1) and Steven M. Gordon (a1) (a3)...


Corresponding author

Cleveland Clinic Foundation, Department of Infectious Diseases, 9500 Euclid Avenue, Mailstop S32, Cleveland, Ohio 44195 (


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2.Ruben, FL, Norden, CW, Schuster, N. Analysis of a community hospital employee tuberculosis screening program 31 months after its inception. Am Rev Respir Dis 1997;115:2328.
3.Menzies, D, Schwartzman, K. Management of latent tuberculosis infection in immigrants. N Engl J Med 2003;348:12891292.
4.Chan, JC, Tabak, JI. Risk of tuberculous infection among house staff in an urban teaching hospital. South Med J 1985;78:10611064.
5.Mazurek, GH, Jereb, J, Lobue, P, et al.Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC). Guidelines for using the QuantiFERON-TB-Gold Test for detecting Mycobacterium tuberculosis infection, United States (published correction appears in MMWR Morb Mortal Wkly Rep 2005;54:1288). MMWR Recomm Rep 2005;54(RR-15):4955.
6.Fraser, TG, Kowalczyk, J, Schmitt, S, et al.Active tuberculosis in a healthcare worker: are you ready? Infect Control Hosp Epidemiol 2009;30:8082.
7.Parsyan, AE, Saukkonen, J, Barry, MA, Sharnprapai, S, Horsburgh, CR Jr. Predictors of failure to complete treatment for latent tuberculosis infection. J Infect 2007;54:262266.


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