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Do Prolonged Peripherally Inserted Central Venous Catheter Dwell Times Increase the Risk of Bloodstream Infection?

  • Aaron M. Milstone (a1) and Arnab Sengupta (a1)


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Corresponding author

Department of Pediatric Infectious Diseases, Johns Hopkins University, 200 North Wolfe Street/Rubenstein 3141, Baltimore, MD 21287 (,


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1.Lam, S, Scannell, R, Roessler, D, Smith, MA. Peripherally inserted central catheters in an acute-care hospital. Arch Intern Med 1994;154(16):18331837.
2.Funk, D, Gray, J, Plourde, PJ. Two-year trends of peripherally inserted central catheter line complications at a tertiary-care hospital: role of nursing expertise. Infect Control Hosp Epidemiol 2001;22(6):377379.
3.Michel, L, Marsh, HM, McMichan, JC, Southorn, PA, Brewer, NS. Infection of pulmonary artery catheters in critically ill patients. JAMA 1981;245(10):10321036.
4.Damen, J, Van der Tweel, I. Positive tip cultures and related risk factors associated with intravascular catheterization in pediatric cardiac patients. Crit Care Med 1988;16(3):221228.
5.Relio, J, Coll, P, Net, A, Prats, G. Infection of pulmonary artery catheters: epidemiologic characteristics and multivariate analysis of risk factors. Chest 1993;103(1):132136.
6.Chathas, MK, Paton, JB, Fisher, DE. Percutaneous central venous catheterization: three years' experience in a neonatal intensive care unit. Am J Dis Child 1990;144(11):12461250.
7.Ullman, RF, Gurevich, I, Schoch, PE, Cunha, BA. Colonization and bacteremia related to duration of triple-lumen intravascular catheter placement. Am J Infect Control 1990;18(3):201207.
8.Gertner, J, Herman, B, Pescio, M, Wolff, MA. Risk of infection in prolonged central venous catheterization. Surg Gynecol Obstet 1979;149(4):567570.
9.Casado-Flores, J, Valdivielso-Serna, A, Perez-Iurado, L, et al.Subclavian vein catheterization in critically ill children: analysis of 322 cannulations. Intensive Care Med 1991;17(6):350354.
10.Mermel, LA, McCormick, RD, Springman, SR, Maki, DG. The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular subtyping. Am J Med 1991;91(3B):197S205S.
11.Maki, DG, Stolz, SS, Wheeler, S, Mermel, LA. A prospective, randomized trial of gauze and two polyurethane dressings for site care of pulmonary artery catheters: implications for catheter management. Crit Care Med 1994;22(11):17291737.
12.Cairns, PA, Wilson, DC, McClure, BG, Halliday, HL, McReid, M. Percutaneous central venous catheter use in the very low birth weight neonate. Eur J Pediatr 1995;154(2):145147.
13.Odetola, FO, Moler, FW, Dechert, RE, VanDerElzen, K, Chenoweth, C. Nosocomial catheter-related bloodstream infections in a pediatric intensive care unit: risk and rates associated with various intravascular technologies. Pediatr Crit Care Med 2003;4(4):432436.
14.McLaws, ML, Berry, G. Nonuniform risk of bloodstream infection with increasing central venous catheter-days. Infect Control Hosp Epidemiol 2005; 26(8):715719.
15.Garcia-Teresa, MA, Casado-Flores, J, Delgado Dominguez, MA, et al.Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study. Intensive Care Med 2007;33(3):466476.
16.Goes-Silva, E, Abreu, TF, Frota, AC, Pessoa-Silva, CL, Cunha, AJ, Hofer, CB. Use of peripherally inserted central catheters to prevent catheter-associated bloodstream infection in children. Infect Control Hosp Epidemiol 2009;30(10):10241026.
17.Safdar, N, Kluger, DM, Maki, DG. A review of risk factors for catheter-related bloodstream infection caused by percutaneously inserted, non-cuffed central venous catheters: implications for preventive strategies. Medicine 2002;81(6):466479.
18.Sengupta, A, Lehmann, C, Diener-West, M, Perl, TM, Milstone, AM. Catheter duration and risk of CLA-BSI in neonates with PICCs. Pediatrics 2010;125(4):648653.
19.Timsit, JF, Bruneel, F, Cheval, C, et al.Use of tunneled femoral catheters to prevent catheter-related infection: a randomized, controlled trial. Ann Intern Med 1999;130(9):729735.
20.Timsit, JF. Scheduled replacement of central venous catheters is not necessary. Infect Control Hosp Epidemiol 2000;21(6):371374.
21.Stenzel, JP, Green, TP, Fuhrman, BP, Carlson, PE, Marchessault, RP. Percutaneous central venous catheterization in a pediatric intensive care unit: a survival analysis of complications. Crit Care Med 1989;17(10):984988.
22.O'Grady, NP, Alexander, M, Dellinger, EP, et al.Guidelines for the prevention of intravascular catheter-related infections. Infect Control Hosp Epidemiol 2002;23(12):759769.
23.O'Grady, NP, Alexander, M, Burns, LA, et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention Web site, Published 2009. Accessed November 11, 2009.
24.Berthelot, P, Zeni, F, Pain, P, et al.Catheter infection in intensive care: influence of systematic replacement of central venous catheters on a guide wire every 4 days [in French]. Presse Med 1997;26(23):10891094.
25.Bonawitz, SC, Hammell, EJ, Kirkpatrick, JR. Prevention of central venous catheter sepsis: a prospective randomized trial. Am Surg 1991;57(10):618623.
26.Cobb, DK, High, KP, Sawyer, RG, et al.A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters. N Engl J Med 1992;327(15):10621068.
27.Eyer, S, Brummitt, C, Crossley, K, Siegel, R, Cerra, F. Catheter-related sepsis: prospective, randomized study of three methods of long-term catheter maintenance. Crit Care Med 1990;18(10):10731079.
28.Costello, JM, Morrow, DF, Graham, DA, Potter-Bynoe, G, Sandora, TJ, Laussen, PC. Systematic intervention to reduce central line-associated bloodstream infection rates in a pediatric cardiac intensive care unit. Pediatrics 2008;121(5):915923.
29.Miller, MR, Griswold, M, Harris, JM II, et al.Decreasing PICU catheter-associated bloodstream infections: NACHRI's quality transformation efforts. Pediatrics 2010;125(2):206213.
30.Safdar, N, Maki, DG. Risk of catheter-related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patients. Chest 2005;128(2):489495.
31.Adams-Chapman, I, Stoll, BJ. Prevention of nosocomial infections in the neonatal intensive care unit. JPEN Opin Pediatr 2002;14(2):157164.
32.Ryder, M. Evidence-based practice in the management of vascular access devices for home parenteral nutrition therapy. JPEN J Parenter Enteral Nutr 2006;30(suppl 1):S82-S93, S98S99.
33.Mermel, LA. Prevention of intravascular catheter-related infections. Ann Intern Med 2000;132(5):391402.
34.Rubinson, L, Diette, GB. Best practices for insertion of central venous catheters in intensive-care units to prevent catheter-related bloodstream infections. J Lab Clin Med 2004;143(1):513. Jonge, RC, Polderman, KH, Gemke, RJ. Central venous catheter use in the pediatric patient: mechanical and infectious complications. Pediatr Crit Care Med 2005;6(3):329339.
36.Sketch, MH, Cale, M, Mohiuddin, SM, Booth, RW. Use of percutaneously inserted venous catheters in coronary care units. Chest 1972;62(6):684689.
37.Giuffrida, DJ, Bryan-Brown, CW, Lumb, PD, Kwun, KB, Rhoades, HM. Central vs peripheral venous catheters in critically ill patients. Chest 1986;90(6):806809.
38.Liossis, G, Bardin, C, Papageorgiou, A. Comparison of risks from percutaneous central venous catheters and peripheral lines in infants of extremely low birth weight: a cohort controlled study of infants <1000 g. J Matern Fetal Neonatal Med 2003;13(3):171174.
39.Golombek, SG, Rohan, AJ, Parvez, B, Salice, AL, LaGamma, EF, “Proactive” management of percutaneously inserted central catheters results in decreased incidence of infection in the ELBW population. J Perinatal 2002;22(3):209213.
40.Chlebicki, MP, Teo, EK. Review of peripherally inserted central catheters in the Singapore acute-care hospital. Singapore Med J 2003;44(10):531535.
41.Garland, IS, Alex, CP, Sevallius, IM, et al.Cohort study of the pathogenesis and molecular epidemiology of catheter-related bloodstream infection in neonates with peripherally inserted central venous catheters. Infect Control Hosp Epidemiol 2008;29(3):243249.


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