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Development and Application of an Antibiotic Spectrum Index for Benchmarking Antibiotic Selection Patterns Across Hospitals

  • Jeffrey S. Gerber (a1) (a2), Adam L. Hersh (a3), Matthew P. Kronman (a4), Jason G. Newland (a5), Rachael K. Ross (a1) and Talene A. Metjian (a6)...


Standard metrics for antimicrobial use consider volume but not spectrum of antimicrobial prescribing. We developed an antibiotic spectrum index (ASI) to classify commonly used antibiotics based on activity against important pathogens. The application of this index to hospital antibiotic use reveals how this tool enhances current antimicrobial stewardship metrics.

Infect Control Hosp Epidemiol 2017;38:993–997


Corresponding author

Address correspondence to Jeffrey S. Gerber, MD, PhD, Division of Infectious Diseases, The Children’s Hospital of Philadelphia, CHOP North, Suite 1518, Philadelphia, PA 19104 (


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PREVIOUS PRESENTATION: The work reported here was presented at ID Week 2014 on October 10, 2014, in Philadelphia, Pennsylvania.



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1. Policy statement on antimicrobial stewardship by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS). Infect Control Hosp Epidemiol 2012;33:322–327.
2. Barlam, TF, Cosgrove, SE, Abbo, LM, et al. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 2016;62:e51e77.
3. Moehring, RW, Anderson, DJ, Cochran, RL, Hicks, LA, Srinivasan, A, Dodds Ashley, ES. Expert consensus on metrics to assess the impact of patient-level antimicrobial stewardship interventions in acute-care settings. Clin Infect Dis 2017;64:377383.
4. Gerber, JS, Kronman, MP, Ross, RK, et al. Identifying targets for antimicrobial stewardship in children’s hospitals. Infect Control Hosp Epidemiol 2013;34:12521258.
5. Ross, RK, Hersh, AL, Kronman, MP, et al. Impact of Infectious Diseases Society of America/Pediatric Infectious Diseases Society guidelines on treatment of community-acquired pneumonia in hospitalized children. Clin Infect Dis 2014;58:834838.
6. Newman, RE, Hedican, EB, Herigon, JC, Williams, DD, Williams, AR, Newland, JG. Impact of a guideline on management of children hospitalized with community-acquired pneumonia. Pediatrics 2012;129:e597e604.
7. Fitzmaurice, GM, Laird, NM. Applied Longitudinal Analysis. 2nd ed. Hoboken, NJ: Wiley & Sons; 2011.
8. Madaras-Kelly, K, Jones, M, Remington, R, Hill, N, Huttner, B, Samore, M. Development of an antibiotic spectrum score based on veterans affairs culture and susceptibility data for the purpose of measuring antibiotic de-escalation: a modified Delphi approach. Infect Control Hosp Epidemiol 2014;35:11031113.
9. Stenehjem, E, Hersh, AL, Sheng, X, et al. Antibiotic use in small community hospitals. Clin Infect Dis 2016;63:12731280.
10. Antimicrobial use and resistance (AUR) module. Centers for Disease Control and Prevention website. Published 2017. Accessed April 1, 2017.


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